Acanthosis nigricans

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Classification according to ICD-10
L83 Acanthosis nigricans
Q82.8 Other specified congenital skin malformations
ICD-10 online (WHO version 2019)
Acanthosis nigricans in the right armpit, plus pendulous fibromas

Under Acanthosis nigricans a group of clinically similar skin diseases is different etiology summarized by a acanthosis symmetrical with most dirty brown to gray lesions mostly in the armpits, flexures, is characterized in the neck or groin. An increased insulin concentration often plays an important pathogenetically , so that the disease occurs more frequently in patients with insulinoma , type 2 diabetes mellitus and obesity . It occurs mostly in women ( gynecotropia ).

The Pseudoacanthosis nigricans mainly affects more pigmented Obese and appear diffuse. The causes are unknown.

to form

Benign forms

Acanthosis occurs as a dominant hereditary acanthosis nigricans benigna (also Pseudoacanthosis nigricans ) mostly in childhood and often improves after puberty.

Malignant forms

As acanthosis nigricans maligna , malignant forms of acanthosis almost always appear as paraneoplastic syndrome, mostly in connection with adenocarcinoma of the stomach, with then mostly strong pigmentation on the arms and legs.

diagnosis

To differentiate between benign and malignant acanthosis, a primary tumor should be found. The laboratory determination of CEA and alpha-1-fetoprotein is a further step here . Invasive examinations include an endoscopic examination of the gastrointestinal tract, a laparatomy and a bronchoscopy .

therapy

Most of the time, treating the underlying disease is enough. Alternatively, retinoids can be given.

See also

Single receipts

  1. ↑ VP Jyotsna, N. Raizada, S. Chakraborty, S. Pal: Acanthosis nigricans in insulinoma. In: Indian journal of endocrinology and metabolism. Volume 18, number 5, September 2014, p. 739, doi: 10.4103 / 2230-8210.139223 , PMID 25285297 , PMC 4171903 (free full text).
  2. ↑ Entry on Acanthosis nigricans in Flexikon , a Wiki of the DocCheck company , accessed on March 12, 2013.
  3. ↑ Entry on Pseudoacanthosis nigricans in Flexikon , a Wiki of the DocCheck company , accessed on March 12, 2013.

literature

  • Matthiessen, Gerda (1965): Clinical follow-up observations in acanthosis nigricans. Hamburg (Univ., Diss. Med.).

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