Achim Gruber

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Achim Gruber (2018)

Achim D. Gruber (born May 14, 1966 in Marl ) is a German veterinarian , animal pathologist and non-fiction author. He heads the Institute for Animal Pathology at the Free University of Berlin .

Life

After studying at the University of Veterinary Medicine Hanover (TiHo) from 1986 to 1991 , Achim Gruber obtained his doctorate at the Institute for Pathology there in 1994 on the development of virus-induced brain malformations in cattle. After two years as an assistant, he moved to the Department of Molecular Medicine at Cornell University College of Veterinary Medicine, Ithaca , USA, where he was awarded the Doctor of Philosophy (Ph.D.) degree in Molecular Biology of Cancer in 1999 . After his habilitation, qualification as a specialist veterinarian in pathology and appointment as a diploma from the European College of Veterinary Pathologists in 2001, he worked as a senior assistant at the TiHo before he was appointed C3 professor for molecular animal pathology in 2003. Since 2004 he has headed the Institute for Animal Pathology at the Department of Veterinary Medicine at Freie Universität Berlin , where he was also Dean of Research from 2013 to 2019.

Work areas

In addition to training young veterinarians as well as diagnostic and research activities in the medicine of domestic, farm, zoo and wild animals, Gruber has been working in molecular and comparative pathology since his doctorate. He worked on the CLCA gene family, the first member of which was cloned in 1995. In addition, he has been researching the immune mechanisms of mucous membranes and the lungs since 2003 within the framework of special research areas funded by the German Research Foundation, as well as nanocarriers in the treatment of inflammatory skin diseases. In addition, his diagnostic activities and collaborations resulted in several individual research projects, such as the discovery and characterization of a new parasite from the coccidia group called Sarcocystis Calchasi , which attacks pigeons.

Gruber drew the public's attention in 2019 in his non-fiction book "Das Kuscheltierdrama" to grievances and blatant undesirable developments in pets. The focus is on defective breeding, the bizarre consequences of humanization of pets and diseases that can be transmitted between animals and humans ( zoonoses ). The background to this is the increasing importance of pets up to the role as a substitute for social partners in a lonely society, with detrimental consequences for their health and species justice. "Das Kuscheltierdrama" was on the Spiegel bestseller list for over seven weeks.

Gruber has been a board member of the European Society of Veterinary Pathology since 2013 and a full member of the Berlin-Brandenburg Academy of Sciences since 2018

Honourings and prices

  • Carl Norden Memorial Prize of the University of Veterinary Medicine Hannover (1994)
  • Gustav Rosenberger Memorial Prize (1996)
  • Award of the Academy for Animal Health for outstanding work in the field of molecular pathology (2000)

Works

Editing

  • General pathology for veterinary medicine, Enke Verlag, 2015, ISBN 978-3-8304-1285-4 . (Editor with Wolfgang Baumgärtner).
  • Special pathology for veterinary medicine , Enke Verlag, 2015, ISBN 978-3-8304-1172-7 . (Editor with Wolfgang Baumgärtner).

Non-fiction

  • Achim Gruber: The cuddly toy drama. A veterinary pathologist on the silent suffering of pets . Droemer Verlag, 2019, ISBN 978-3-426-27781-2 .

Research contributions (selection)

  • Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2 + -activated Cl− channel proteins. AD Gruber, RC Elble, HL Ji, KD Schreur, CM Fuller, BU Pauli. Genomics 54 (2): 200-214, 1998
  • Discovery and cloning of the CLCA gene family . AD Gruber, RC Elble, BU Pauli. Current Topics in Membranes, 367-388, 2002
  • The CLCA Gene Family A Novel Family of Putative Chloride Channels . AD Gruber, CM Fuller, RC Elble, DJ Benos, BU Pauli. Current Genomics 1 (2), 201-222, 2000
  • Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles. R Klopfleisch, D Lenze, M Hummel, AD Gruber. BMC Cancer 10 (1), 618, 2010
  • Proteome of metastatic canine mammary carcinomas: similarities to and differences from human breast cancer. R Klopfleisch, P Klose, C Weise, A Bondzio, G Multhaup, R Einspanier, AD Gruber. Journal of Proteome Research 9 (12), 6380-6391, 2010
  • Both cleavage products of the mCLCA3 protein are secreted soluble proteins . L Mundhenk, M Alfalah, RC Elble, BU Pauli, HY Naim, AD Gruber. Journal of Biological Chemistry 281 (40), 30072-30080, 2006
  • Overview on the localization of nanoparticles in tissue and cellular context by different imaging techniques . A Ostrowski, D Nordmeyer, A Boreham, C Holzhausen, L Mundhenk, Graf, MC Meinke, A Vogt, S Hadam, J Lademann, E Rühl, U Alexiev, AD Gruber. Beilstein journal of nanotechnology 6 (1), 263-280, 2015
  • Sarcocystis calchasi is distinct to Sarcocystis columbae sp. nov. from the wood pigeon (Columba palumbus) and Sarcocystis sp. from the sparrowhawk (Accipiter nisus). P Olias, L Olias, M Lierz, H Mehlhorn, AD Gruber. Veterinary parasitology 171 (1-2), 7-14, 2010
  • The metastatic cascade is reflected in the transcriptome of metastatic canine mammary carcinomas .
  • mCLCA3 modulates IL-17 and CXCL-1 induction and leukocyte recruitment in murine Staphylococcus aureus pneumonia .
  • Mechanisms of tumor resistance against chemotherapeutic agents in veterinary oncology.
  • Digital image analyzes on whole-lung slides in mouse models of acute pneumonia.
  • Interspecies diversity of chloride channel regulators, calcium-activated 3 genes .
  • The Family of Chloride Channel Regulator, Calcium-activated Proteins in the Feline Respiratory Tract: A Comparative Perspective on Airway Diseases in Man and Animal Models.

Web links

Individual evidence

  1. ↑ a b c d TIHO indicator. 33rd year children's lecture in the TiHo GdF general meeting. In: docplayer.org . University of Veterinary Medicine Hannover, April 2004, p. 11 , accessed on February 24, 2020 .
  2. ↑ a b About Achim Gruber. Job description of the university. Free University of Berlin , October 14, 2005, accessed on February 18, 2020 .
  3. ↑ Dissertation: Detection of the virus of the bovine viral diarrhea in the brain by means of polymerase chain reaction and in situ hybridization . Proof in the catalog of the library of the University of Veterinary Medicine Hannover.
  4. ↑ A novel family of calcium-activated chloride channels homologous to lung endothelial cell adhesion molecule-1: Molecular cloning, biochemical characterization, and functional analyzes , evidence in the catalog of Cornell University
  5. ↑ Habilitation thesis: Identification, molecular characterization and genomic localization of a new family of calcium-activated chloride channels in cattle, mice and humans . Proof in the catalog of the library of the University of Veterinary Medicine Hannover.
  6. ↑ Wolfgang Baumgärtner, Achim Dieter Gruber (ed.): General pathology for veterinary medicine . Information about the publisher. Georg Thieme Verlag, 2015, ISBN 978-3-8304-1286-1 , p. 13 ( limited preview in Google Book search).
  7. ^ F. Javier Alvarez-Leefmans, Eric Delpire: Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases . Academic Press, 2009, ISBN 978-0-08-092203-4 , pp. 247–248 ( limited preview in Google Book search).
  8. ↑ Michael Lange: Achim Gruber: "Das Kuscheltierdrama" - An animal pathologist unpacks. Deutschlandfunk Kultur , March 19, 2019, accessed on February 21, 2020 .
  9. ↑ "Don't give guinea pigs to children!" Talk about the dark side of our love for animals. In: Stern.de . March 10, 2019, accessed February 21, 2020 .
  10. ↑ Tanja Neuvians: Book review: Loved to death. In: Spektrum.de. May 4, 2019, accessed February 21, 2020 .
  11. ↑ Kristin Kielon: How people love their pets to death | MDR.DE. In: mdr knowledge. Mitteldeutscher Rundfunk, May 19, 2019, accessed on February 21, 2020 .
  12. ↑ book report. Retrieved on February 10, 2020 (German).
  13. ↑ BBAW: CV Gruber. (PDF) Berlin-Brandenburg Academy of Sciences and Humanities, February 5, 2020, accessed on February 5, 2020 .
  14. ↑ Sponsorship award awarded to scientists at the BFAV. Science Information Service , June 29, 2000, accessed on February 24, 2020 .
  15. ^ R. Klopfleisch, D. Lenze, M. Hummel, AD Gruber: The metastatic cascade is reflected in the transcriptome of metastatic canine mammary carcinomas . In: Veterinary Journal (London, England: 1997) . tape 190 , no. 2 , November 2011, ISSN  1532-2971 , p. 236-243 , doi : 10.1016 / j.tvjl.2010.10.018 , PMID 21112801 .
  16. ↑ Kristina Dietert, Katrin Reppe, Lars Mundhenk, Martin Witzenrath, Achim D. Gruber: mCLCA3 Modulates IL-17 and CXCL-1 Induction and Leukocyte Recruitment in Murine Staphylococcus aureus Pneumonia . In: PLOS ONE . tape 9 , no. 7 , July 17, 2014, ISSN  1932-6203 , p. e102606 , doi : 10.1371 / journal.pone.0102606 , PMID 25033194 , PMC 4102496 (free full text) - ( plos.org [accessed February 24, 2020]).
  17. ^ R. Klopfleisch, B. Kohn, AD Gruber: Mechanisms of tumor resistance against chemotherapeutic agents in veterinary oncology . In: Veterinary Journal (London, England: 1997) . tape 207 , January 2016, ISSN  1532-2971 , p. 63-72 , doi : 10.1016 / j.tvjl.2015.06.015 , PMID 26526523 .
  18. ↑ Kristina Dietert, Geraldine Nouailles, Birgitt Gutbier, Katrin Reppe, Sarah Berger: Digital Image Analyzes on Whole-Lung Slides in Mouse Models of Acute Pneumonia . In: American Journal of Respiratory Cell and Molecular Biology . tape 58 , no. 4 , April 2018, ISSN  1535-4989 , p. 440-448 , doi : 10.1165 / rcmb.2017-0337MA , PMID 29361238 .
  19. ↑ Lars Mundhenk, Nancy A. Erickson, Nikolai Klymiuk, Achim D. Gruber: Interspecies diversity of chloride channel regulators, calcium-activated 3 genes . In: PLOS ONE . tape 13 , no. 1 , January 18, 2018, ISSN  1932-6203 , p. e0191512 , doi : 10.1371 / journal.pone.0191512 , PMID 29346439 , PMC 5773202 (free full text) - ( plos.org [accessed February 18, 2020]).
  20. ↑ NA Erickson, AD Gruber, L. Mundhenk: The Family of Chloride Channel Regulator, Calcium-activated Proteins in the Feline Respiratory Tract: A Comparative Perspective on Airway Diseases in Man and Animal Models . In: Journal of Comparative Pathology . tape 174 , January 2020, ISSN  1532-3129 , p. 39-53 , doi : 10.1016 / j.jcpa.2019.10.193 , PMID 31955802 .
personal data
SURNAME Gruber, Achim
ALTERNATIVE NAMES Gruber, Achim D.
BRIEF DESCRIPTION German animal pathologist and author
DATE OF BIRTH May 14, 1966
PLACE OF BIRTH Marl