Acute cholinergic syndrome
| Classification according to ICD-10 | |
|---|---|
| T44 | Poisoning from drugs that primarily affect the autonomic nervous system |
| ICD-10 online (WHO version 2019) | |
An acute cholinergic syndrome (also muscarinic syndrome ) is a pathological condition of the autonomic nervous system in which the vagus nerve ( parasympathetic nerve ) is overstimulated.
root cause
The syndrome usually occurs as a result of undesired drug effects or poisoning, but also after insect bites, see acetylcholine in animal and plant poisons .
It can occur as a temporary side effect when given irinotecan, which is used in chemotherapy .
Furthermore, pesticides and nerve agents such as sarin can lead to an acute cholinergic syndrome.
Clinical manifestations
The symptoms are:
- diarrhea
- sweat
- stomach pain
- watery eyes
- Visual disturbances with narrow pupils
- increased salivation
- chills
- Conjunctivitis
- Dilation of blood vessels with low blood pressure
- Drowsiness, malaise, dizziness
The frequency of occurrence in oncological treatment is given as 1%.
therapy
The treatment is performed by atropine , which, however, only a partial antidote ( antidote group), as atropine mainly binds to the muscarinic acetylcholine receptors, but not at the nicotinic acetylcholine receptors.
See also
literature
- MJ Hsieh, ZS Yen, SC Chen, CC Fang: Acute cholinergic syndrome following ingestion of contaminated herbal extract. In: Emergency medicine journal: EMJ. Volume 25, number 11, November 2008, pp. 781-782, doi : 10.1136 / emj.2008.060889 . PMID 18955628 .
Individual evidence
- ↑ https://medikamio.com/de-de/medikamente/irinotecan-evepacks-20-mgml-zentrat-zur-bildung-einer-infusionsloesung/pil
- ↑ Fluoridealert
- ↑ Jurnalonko
- ↑ Uni Tübingen ( Memento of the original from August 19, 2014 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice.
