Aminopenicillins

Aminopenicillins are drugs that are used as antibiotics . They are characterized by the addition of an amino group to the benzyl residue of penicillin . This chemical modification leads to an expansion of the spectrum of activity. The most important representatives of the aminopenicillins are amoxicillin and ampicillin .

Aminopenicillins are not β-lactamase stable. Their effectiveness against gram-positive bacteria is only about half to a fifth of that of benzylpenicillin , but they are about four to ten times more effective against gram-negative germs. Aminopenicillins are well tolerated and can also be used orally .

Aminopenicillins are:

• Amoxicillin
• Ampicillin
• Bacampicillin
• Pivampicillin
• Sultamicillin

Acylaminopenicillins are chemically similar, but by expanding the spectrum they also have an effect on gram-negative and anaerobic bacteria.

literature

Wolfgang Löscher et al .: Pharmacotherapy in pets and farm animals . Parey, 7th ed. 2006, p. 247. ISBN 3-8304-4160-6