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Anaphylatoxins are degradation products of the immune system of multicellular animals . They are proteins , activated partial complexes of the complement system , which release histamine in acute allergic reactions by triggering mast cell decay . The anaphylatoxins in humans are the components C3a, C4a and C5a activated from C3, C4 and C5 .


Cause anaphylatoxins

  • Smooth muscle spasms , e.g. B. Bronchial spasms
  • Increase in the permeability of the blood capillaries through the release of histamine from mast cells (histamine effect)
  • increasing chemotaxis , i.e. biochemically triggered movement reactions z. B. white blood cells


  • Helmut Hahn, Dietrich Falke, Stefan HE Kaufmann, Uwe Ullmann (eds.): Medical microbiology and infectious diseases . 5th edition. Springer-Verlag, Heidelberg 2004, ISBN 3-540-21971-4 .

See also