Anti-idiotypic antibody
An anti-idiotypic antibody is an antibody that binds to the variable region of another antibody (the idiotype ).
properties
An anti-idiotypic antibody binds to epitopes , in this case called idiotopes , within the variable region of an antibody . The hypothesis of the regulation of the antibody response by anti-idiotypic antibodies ( Network Hypothesis ) was put forward by Niels Jerne in 1974 . Some idiotypic antibodies bind to the paratope of antibodies and thereby competitively inhibit their binding to their epitope. In some cases, the epitope-binding sites on an anti-idiotypic antibody are analogous to the epitope of the bound antibody.
Anti-idiotypic antibodies are, inter alia, for the treatment of B-cell - lymphoma and ovarian carcinoma examined.
literature
- Charles Janeway et al .: Immunobiology. 6th edition. Garland, New York 2005, ISBN 0-8153-4101-6 . (The 5th English edition is available online on the pages of the NCBI Bookshelf, (online) )
- ES Golub: Idiotypes and the network hypothesis. In: Cell. Volume 22, Issue 3, 1980, pp. 641-642. doi: 10.1016 / 0092-8674 (80) 90536-X . PMID 7460006 .
Individual evidence
- ↑ a b Detlev Ganten, Klaus Ruckpaul: Molecular medical principles of rheumatic diseases. Springer-Verlag, 2013, ISBN 978-3-642-55803-0 , pp. 168-169.
- ↑ Y. Pan, SC Yuhasz, LM Amzel: Anti-idiotypic antibodies: biological function and structural studies. In: FASEB J. Volume 9, Issue 1, 1995, pp. 43-49. PMID 7821758 .
- ^ F. Benvenuti, M. Cesco-Gaspere, OR Burrone: Anti-idiotypic DNA vaccines for B-cell lymphoma therapy. In: Front Biosci. Volume 7, 2002, pp. D228-d34. PMID 11779689 .
- ^ DO Bauerschlag, C. Schem, K. Baumann, P. Harter, F. Hilpert, U. Wagner, A. du Bois, J. Pfisterer: Anti-idiotypic antibody abagovomab in advanced ovarian cancer. In: Future Oncol. Volume 4, Issue 6, 2008, pp. 769-773. doi: 10.2217 / 14796694.4.6.769 . PMID 19086842 .