S-arrestin
| S-arrestin | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 405 amino acids | |
| Cofactor | Ca 2+ | |
| Identifier | ||
| Gene name | SAY | |
| External IDs | ||
| Occurrence | ||
| Homology family | S-arrestin | |
| Parent taxon | Bilateral animals | |
S-arrestin is a protein that plays an important role in the processing of light stimuli in the eyes of bilateral animals . It obviously limits the transmission of the light stimulus. In humans, S-arrestin is produced in the retina and pineal gland . It can represent the antigen in autoimmune uveitis . Mutations in SAG - gene can for Oguchi's syndrome, a rare inherited form of night blindness , lead.
S-Arrestin is a crucial component in the shutdown and regulation of the signal cascade induced by incident light. It combines temporarily with active rhodopsin and thus prevents other transducin molecules in the signal cascade from being activated by rhodopsin.
Individual evidence
- ↑ UniProt P10523
- ^ Gurevich EV, Gurevich VV: Arrestins: ubiquitous regulators of cellular signaling pathways . In: Genome Biol. . 7, No. 9, 2006, p. 236. doi : 10.1186 / gb-2006-7-9-236 . PMID 17020596 . PMC 1794542 (free full text).