Aschheim-Zondek reaction

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The rabbit test (AZR), named after the gynecologist Selmar Aschheim (1878-1965) and Bernhard Zondek (1891-1966) was one of 1,927 frequently used until 1960 biological pregnancy test : With the release of the hormone chorionic gonadotropin was in a early stage pregnancy can be established in a woman.

method

During the test, some early morning urine from the woman to be examined was injected under the skin of some young (infantile) female mice . That is why the evidence was also called the mouse test. If the pregnancy hormone was present in human urine, then the ovaries of the mice reacted by ovulating after 48 hours . It indicated that the woman was likely pregnant. However, the evidence required the autopsy of the test animals - in contrast to the frog test , a likewise obsolete method for the early detection of pregnancy, in which the animals were not killed.

The Friedman test is also out of date . Pregnancy was proven by the reaction of the rabbit's ovaries to human urine.

Quote

In Alfred Andersch's novel Die Rote , the protagonist Franziska suspects a pregnancy. That's why she consults the gynecologist Campo Manin Alessandri in Venice , whom the jewelry dealer Aldo Lopez recommended to her. The doctor Alessandri finally says to his patient: At this early stage there is no point in my examining her, we can only do the mouse test.

Individual evidence

  1. Horst Kremling : On the development of clinical diagnostics. In: Würzburger medical history reports 23, 2004, pp. 233–261; here: p. 240.
  2. Der Spiegel, issue 35/1949.
  3. Alfred Andersch: The Red. Book guild Gutenberg, Frankfurt am Main 1962, p. 290f.