Aspidosperma alkaloids
Aspidosperma alkaloids are natural substances of the indole alkaloid type. You come u. a. in Aspidosperma species in the dog venom family ( Apocynaceae ).
Occurrence
The aspidospermidine and quebrachamine were isolated from the quebracho tree ( Aspidosperma quebracho-blanco ) native to Argentina, Bolivia and Chile . Aspidospermin has also been isolated from this and other Aspidosperma species. The bark of the quebracho tree is traded as quebracho bark. Extracts of the drug have a breathtaking effect and were used to relieve asthma.
Representative
There are more than a hundred aspidosperma alkaloids. Important representatives are u. a. Aspidospermine , aspidospermidine , quebrachamine , yohimbine and vincamine .
Aspidospermine
(CAS No. 466-49-9)
Aspidospermidine
(CAS No. 2912-09-6)
Quebrachamine
(CAS No. 4850-21-9)
Vincamine
(CAS No. 1617-90-9)
-Aspidospermin_Structural_Formula_V2.svg)
-Aspidospermidin_Structural_Formula_V1.svg)
-Quebrachamine_Structural_Formula_V1.svg)
-Vincamine_Structural_Formula_V2.svg)
Stereochemistry
If in this article or in the scientific literature one of these alkaloids is named without any additional name, it actually means:
- Aspidospermin for (-) - aspidospermin,
- Aspidospermidine for (+) - aspidospermidine,
- Quebrachamin for (-) - quebrachamin and
- Vincamine for (+) - vincamine.
The expressions in brackets stand for the sense of rotation of the optical activity of these substances.
Individual evidence
- ↑ a b Entry on Aspidosperma alkaloids. In: Römpp Online . Georg Thieme Verlag, accessed on April 21, 2020.
- ↑ E. Breitmaier: Alkaloids . Springer Fachmedien, Wiesbaden 1997, ISBN 978-3-519-03542-8 , pp. 50 f .