Bradykinin receptor

The bradykinin receptor is one of the membrane receptors .

All eukaryotic and prokaryotic cells contain such receptors in order to be able to exchange information with the environment. Chemical substances, light, mechanical forces, temperature fluctuations or electrochemical impulses can serve as signals from these receptors. The biological responses to these signals are vital processes such as cell movement , cell division , cell metabolism , morphogenesis and differentiation .

The bradykinin receptor is a G protein-coupled receptor (GPCR) which is activated by the binding of a ligand . GPCR is an important family of transmembrane receptors. Above all, G proteins of group Gq11 and Gαi are activated after binding the ligand.

Types of bradykinin receptor

There are B ₁ and B ₂ bradykinin receptors; both receptors are GPCRs. The B ₂ bradykinin receptor is ubiquitously expressed, but the B ₁ type only after injuries. It is upregulated by proinflammatory cytokines. Unlike the injury-induced type, the B ₂ bradykinin receptor shows rapid desensitization and internalization after ligand binding.

Web links

pharmasquare : Molecular drug mechanisms , GPCR module

Bradykinin receptor B1 in IUPHAR

Bradykinin receptor B2 in IUPHAR

Individual evidence

↑ ^a ^b Leschner, Jasmin: The bradykinin B1 and B2 receptors as a model for the investigation of the regulation of G-protein-coupled receptors. Dissertation, LMU Munich: Medical Faculty . 2013 ( uni-muenchen.de [accessed June 4, 2020]).

[:0-1] Leschner, Jasmin: The bradykinin B1 and B2 receptors as a model for the investigation of the regulation of G-protein-coupled receptors. Dissertation, LMU Munich: Medical Faculty . 2013 ( uni-muenchen.de [accessed June 4, 2020]).