CCAAT / enhancer binding proteins

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CCAAT / enhancer binding proteins
Secondary to quaternary structure Homo- / heterodimer
Identifier
Gene name (s) CEBPA , CEBPB , CEBPD , CEBPE , CEBPG , CEBPZ
Occurrence
Parent taxon Vertebrates

The CCAAT / enhancer binding proteins (C / EBP) are a family of transcription factors that regulate the gene expression of enzymes of several metabolic pathways in vertebrates . There are six different C / EBPs in humans; they all bind to the nucleotide sequence CCAAT in the genome , which occurs in the promoter area of ​​the respective regulated genes . The C / EBP are among the transcription factors with a bZIP domain .

C / EBPα is a central regulator of energy metabolism; Mice without C / EBPα show a dramatically altered metabolism with hypoglycaemia and a lack of adipose tissue.

C / EBPβ (LAP) is involved in the immune response and inflammation and is particularly expressed in T lymphocytes . It can both slow down and accelerate proliferation , and at the same time it exhibits tumor suppressor- like and proto-oncogene properties. In particular, C / EBPβ is necessary for the inhibitory effect of TGF-β on the expression of the proto-oncogene protein Myc and it regulates the expression of interleukin-6 .

Mice without C / EBPδ do not form any sodium lactate symporter transport proteins in their kidney cells . C / EBPε is involved in myelopoiesis , C / EBPγ regulates the expression of GCSF and C / EBPζ that of HSP70 .

Individual evidence

  1. ↑ Lekstrom-Himes J, Xanthopoulos KG: Biological role of the CCAAT / enhancer-binding protein family of transcription factors . In: J. Biol. Chem. . 273, No. 44, October 1998, pp. 28545-8. PMID 9786841 .
  2. ↑ McKnight SL, Lane MD, Gluecksohn-Waelsch S: Is CCAAT / enhancer-binding protein a central regulator of energy metabolism? . In: Genes Dev. . 3, No. 12B, December 1989, pp. 2021-4. PMID 2697636 .
  3. ↑ Wang ND, Finegold MJ, Bradley A, et al. : Impaired energy homeostasis in C / EBP alpha knockout mice . In: Science . 269, No. 5227, August 1995, pp. 1108-12. PMID 7652557 .
  4. ↑ C / EBPα.  In: Online Mendelian Inheritance in Man . (English).
  5. ↑ Jean E. Vance: Biochemistry of lipids, lipoproteins, and membranes . Elsevier, 2002, ISBN 0-444-51138-5 , pp. 265 ff .
  6. ↑ UniProt P17676 .
  7. ↑ George F. Vande Woude: Advances in Cancer Research , Volume 95 . Academic Press, 2006, ISBN 0-12-374224-2 , pp. 220 ff .
  8. ↑ C / EBP δ.  In: Online Mendelian Inheritance in Man . (English).
  9. ↑ C / EBPε.  In: Online Mendelian Inheritance in Man . (English).
  10. ↑ C / EBPγ.  In: Online Mendelian Inheritance in Man . (English).
  11. ↑ C / EBPζ.  In: Online Mendelian Inheritance in Man . (English).