CCL16

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CCL16
other names
  • Chemokine (CC Motif) ligand 16
  • SCYA16
  • NCC4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 16
  • Lymphocyte And Monocyte Chemoattractant
  • Liver-Expressed Chemokine
  • IL-10 Inducible Chemokines
  • Chemokine LEC
  • Monotactin-1
  • ILINCK
  • HCC-4
  • Mtn-1
  • LCC-1
  • CKb12
  • SCYL4
  • LEC
Properties of human protein
Mass / length primary structure 120 amino acids, 13600 Da
Identifier
External IDs

CCL16 ( English CC chemokine ligand 16 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL8 is involved in inflammatory processes. It is chemotactic for and activates various immune cells , including monocytes and T lymphocytes . CCL16 is produced in the liver , thymus and spleen . CCL16 is induced in monocytes by IL-10 , IFN-γ and bacterial lipopolysaccharides . CCL16 binds to CCR1 , CCR2 , CCR5 and CCR8 .

Individual evidence

  1. ↑ Youn et al. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. Biochem. Biophys. Res. Commun. 247: 217-222 (1998).
  2. ↑ Nomiyama et al. Human CC chemokine liver-expressed chemokine / CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes. Int Immunol. 2001 Aug; 13 (8): 1021-9.
  3. ↑ Howard et al. LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. Blood. 2000 Aug 1; 96 (3): 840-5.