CCL18

CCL18
other names	Chemokine (CC Motif) Ligand 18 (Pulmonary And Activation-Regulated); SCYA18; AMAC1; DCCK1; PARC; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 18, Pulmonary And Activation-Regulated; Alternative Macrophage Activation-Associated CC Chemokine 1; Macrophage Inflammatory Protein 4; Dendritic Cell Chemokine 1; CKb7; MIP4;
	Available structural data : 4MHE
Properties of human protein
Mass / length primary structure	89 amino acids, 9849 Da
Identifier
External IDs	GeneCards : CCL18 ; OMIM : 603757 ; UniProt : P55774 ;

CCL18 ( English CC chemokine ligand 18 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL18 is involved in inflammatory processes. As a preprotein in the endoplasmic reticulum, it is shortened to its active form of 69 amino acids. It is made by dendritic cells , monocytes and macrophages , but not by T cells or B cells . CCL18 is induced by IL-10 , IL-4 and IL-13 , i.e. rather by cytokines that activate TH2 cells or a humoral immune response or immunosuppression . Interferon-gamma inhibits the formation of CCL18.

CCL18 binds to the PITPNM3 , GPR30 and CCR8 receptors on other cells. CCL18 is chemotactic for various immune cells including naive T cells, regulatory T cells , TH2 cells, immunosuppressive and immature dendritic cells, basophils, and B cells (naive and effector B cells). The regulatory T cells bound by CCL18 are Foxp3 negative and secrete IL-10.

Individual evidence

↑ K. Hieshima, T. Imai, M. Baba, K. Shoudai, K. Ishizuka, T. Nakagawa, J. Tsuruta, M. Takeya, Y. Sakaki, K. Takatsuki, R. Miura, G. Opdenakker, J Van Damme, O. Yoshie, H. Nomiyama: A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha / LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. In: Journal of Immunology (Baltimore, Md.: 1950). Vol. 159, number 3, August 1997, pp. 1140-1149, PMID 9233607 .
↑ ^a ^b ^c ^d Bellinghausen I, Reuter S, Martin H, Maxeiner J, Luxemburger U, Türeci Ö, Grabbe S, Taube C, Saloga J: Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity . In: J. Allergy Clin. Immunol. . 130, No. 6, December 2012, pp. 1384-93. doi : 10.1016 / j.jaci.2012.08.039 . PMID 23102918 .
↑ Ferrara G, Bleck B, Richeldi L, Reibman J, Fabbri LM, Rom WN, Condos R: Mycobacterium tuberculosis induces CCL18 expression in human macrophages . In: Scand. J. Immunol. . 68, No. 6, December 2008, pp. 668-74. doi : 10.1111 / j.1365-3083.2008.02182.x . PMID 18959625 .
↑ ^a ^b Schraufstatter IU, Zhao M, Khaldoyanidi SK, Discipio RG: The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum . In: Immunology . 135, No. 4, April 2012, pp. 287-98. doi : 10.1111 / j.1365-2567.2011.03541.x . PMID 22117697 . PMC 3372745 (free full text).
↑ ^a ^b Vulcano M, Struyf S, Scapini P, Cassatella M, Bernasconi S, Bonecchi R, Calleri A, Penna G, Adorini L, Luini W, Mantovani A, Van Damme J, Sozzani S: Unique regulation of CCL18 production by maturing dendritic cells . In: J. Immunol. . 170, No. 7, April 2003, pp. 3843-9. doi : 10.4049 / jimmunol.170.7.3843 . PMID 12646652 .
↑ Adema GJ, Hartgers F, Verstraten R, de Vries E, Marland G, Menon S, Foster J, Xu Y, Nooyen P, McClanahan T, Bacon KB, Figdor CG: A dendritic-cell-derived CC chemokine that preferentially attracts naive T cells . In: Nature . 387, No. 6634, June 1997, pp. 713-7. doi : 10.1038 / 42716 . PMID 9192897 .
↑ Chenivesse C, Chang Y, Azzaoui I, Ait Yahia S, Morales O, Plé C, Foussat A, Tonnel AB, Delhem N, Yssel H, Vorng H, Wallaert B, Tsicopoulos A: Pulmonary CCL18 recruits human regulatory T cells . In: J. Immunol. . 189, No. 1, July 2012, pp. 128-37. doi : 10.4049 / jimmunol.1003616 . PMID 22649201 .
↑ ^a ^b de Nadaï P, Charbonnier AS, Chenivesse C, Sénéchal S, Fournier C, Gilet J, Vorng H, Chang Y, Gosset P, Wallaert B, Tonnel AB, Lassalle P, Tsicopoulos A: Involvement of CCL18 in allergic asthma . In: J. Immunol. . 176, No. 10, May 2006, pp. 6286-93. doi : 10.4049 / jimmunol.176.10.6286 . PMID 16670340 .
↑ E. Schutyser, A. Richmond, J. Van Damme: Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes. In: Journal of leukocyte biology. Volume 78, number 1, July 2005, pp. 14-26, doi : 10.1189 / jlb.1204712 , PMID 15784687 , PMC 2665283 (free full text).

[1] K. Hieshima, T. Imai, M. Baba, K. Shoudai, K. Ishizuka, T. Nakagawa, J. Tsuruta, M. Takeya, Y. Sakaki, K. Takatsuki, R. Miura, G. Opdenakker, J Van Damme, O. Yoshie, H. Nomiyama: A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha / LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. In: Journal of Immunology (Baltimore, Md.: 1950). Vol. 159, number 3, August 1997, pp. 1140-1149, PMID 9233607 .

[PMID23102918-2] Bellinghausen I, Reuter S, Martin H, Maxeiner J, Luxemburger U, Türeci Ö, Grabbe S, Taube C, Saloga J: Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity . In: J. Allergy Clin. Immunol. . 130, No. 6, December 2012, pp. 1384-93. doi : 10.1016 / j.jaci.2012.08.039 . PMID 23102918 .

[PMID18959625-3] Ferrara G, Bleck B, Richeldi L, Reibman J, Fabbri LM, Rom WN, Condos R: Mycobacterium tuberculosis induces CCL18 expression in human macrophages . In: Scand. J. Immunol. . 68, No. 6, December 2008, pp. 668-74. doi : 10.1111 / j.1365-3083.2008.02182.x . PMID 18959625 .

[PMID22117697-4] Schraufstatter IU, Zhao M, Khaldoyanidi SK, Discipio RG: The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum . In: Immunology . 135, No. 4, April 2012, pp. 287-98. doi : 10.1111 / j.1365-2567.2011.03541.x . PMID 22117697 . PMC 3372745 (free full text).

[PMID12646652_11-5] Vulcano M, Struyf S, Scapini P, Cassatella M, Bernasconi S, Bonecchi R, Calleri A, Penna G, Adorini L, Luini W, Mantovani A, Van Damme J, Sozzani S: Unique regulation of CCL18 production by maturing dendritic cells . In: J. Immunol. . 170, No. 7, April 2003, pp. 3843-9. doi : 10.4049 / jimmunol.170.7.3843 . PMID 12646652 .

[PMID_9192897-6] Adema GJ, Hartgers F, Verstraten R, de Vries E, Marland G, Menon S, Foster J, Xu Y, Nooyen P, McClanahan T, Bacon KB, Figdor CG: A dendritic-cell-derived CC chemokine that preferentially attracts naive T cells . In: Nature . 387, No. 6634, June 1997, pp. 713-7. doi : 10.1038 / 42716 . PMID 9192897 .

[PMID22649201-7] Chenivesse C, Chang Y, Azzaoui I, Ait Yahia S, Morales O, Plé C, Foussat A, Tonnel AB, Delhem N, Yssel H, Vorng H, Wallaert B, Tsicopoulos A: Pulmonary CCL18 recruits human regulatory T cells . In: J. Immunol. . 189, No. 1, July 2012, pp. 128-37. doi : 10.4049 / jimmunol.1003616 . PMID 22649201 .

[PMID16670340_6-8] Nadaï P, Charbonnier AS, Chenivesse C, Sénéchal S, Fournier C, Gilet J, Vorng H, Chang Y, Gosset P, Wallaert B, Tonnel AB, Lassalle P, Tsicopoulos A: Involvement of CCL18 in allergic asthma . In: J. Immunol. . 176, No. 10, May 2006, pp. 6286-93. doi : 10.4049 / jimmunol.176.10.6286 . PMID 16670340 .

[PMID15784687-9] E. Schutyser, A. Richmond, J. Van Damme: Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes. In: Journal of leukocyte biology. Volume 78, number 1, July 2005, pp. 14-26, doi : 10.1189 / jlb.1204712 , PMID 15784687 , PMC 2665283 (free full text).