CCL19

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CCL19
other names
  • Chemokine (CC Motif) ligand 19
  • CK Beta 11
  • SCYA19
  • MIP3B
  • ELC
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 19
  • Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine
  • Macrophage Inflammatory Protein 3-Beta
  • Exodus 3
  • CKb11
Properties of human protein
Mass / length primary structure 98 amino acids, 10993 Da
Identifier
External IDs
Orthologue
human House mouse
Entrez 6363 100039053
UniProt Q99731 O70460
PubMed search 6363 100039053

CCL19 ( English CC chemokine ligand 19 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL19 is involved in inflammatory processes. It is mainly formed in the thymus and lymph nodes , in moderate amounts in the windpipe and colon, and in small amounts in the stomach , intestines , lungs , kidneys and spleen . It is chemotactic for various immune cells , including dendritic cells and antigen-activated B cells , and CCR7 -positive memory central T cells .

Individual evidence

  1. ↑ Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O: Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7 . In: J. Biol. Chem. . 272, No. 21, 1997, pp. 13803-9. doi : 10.1074 / jbc.272.21.13803 . PMID 9153236 .
  2. ↑ Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ: The leukotriene C (4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC) -dependent mobilization of dendritic cells to lymph nodes . In: Cell . 103, No. 5, 2000, pp. 757-68. doi : 10.1016 / S0092-8674 (00) 00179-3 . PMID 11114332 .
  3. ↑ Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG: Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position . In: Nature . 416, No. 6876, 2002, pp. 94-9. doi : 10.1038 / 416094a . PMID 11882900 .
  4. ↑ Bromley SK, Thomas SY, Luster AD: Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics . In: Nat. Immunol. . 6, No. 9, 2005, pp. 895-901. doi : 10.1038 / ni1240 . PMID 16116469 .