CCL24

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CCL24
other names
  • Chemokine (CC Motif) ligand 24
  • Myeloid Progenitor Inhibitory Factor 2
  • CK beta 6
  • Eotaxin-2
  • SCYA24
  • MPIF2
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 24
  • Eosinophil Chemotactic Protein 2
  • Ckb-6

Existing structural data : 1EIG , 1EIH

Properties of human protein
Mass / length primary structure 119 amino acids, 13134 Da
Identifier
External IDs
Orthologue
human House mouse
Entrez 6369 56221
UniProt O00175 Q9JKC0
PubMed search 6369 56221

CCL24 ( English CC chemokine ligand 24 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL24 is involved in inflammatory processes. It binds to CCR3 and is chemotactic for eosinophils , resting T cells and, to a lesser extent, neutrophils . CCL24 is involved in the development of acetylsalicylic acid- induced asthma .

Individual evidence

  1. ↑ White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM: Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils . In: J. Leukoc. Biol . 62, No. 5, November 1997, pp. 667-75. PMID 9365122 .
  2. ↑ Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz ​​S, Thotakura R, Parmelee D, Gentz ​​R, Garotta G: Molecular and functional characterization of two novel human CC chemokines as inhibitors of two distinct classes of myeloid progenitors . In: J. Med.. . 185, No. 7, April 1997, pp. 1163-72. doi : 10.1084 / jem.185.7.1163 . PMID 9104803 . PMC 2196270 (free full text).
  3. ↑ Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS: Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease . In: Allergy . 65, No. 3, October 2009, pp. 338-346. doi : 10.1111 / j.1398-9995.2009.02158.x . PMID 19796209 .