CCL6
| CC motif chemokine 6 | ||
|---|---|---|
| other names |
Protein C10, small-inducible cytokine A6 |
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| Mass / length primary structure | 116 amino acids , 12,984 Da | |
| Identifier | ||
| External IDs | ||
CC motif chemokine 6 (CCL6) is a protein from the group of chemokines in mice and rats .
properties
CCL6 is induced in the course of inflammation by interferon-gamma , interleukin-1 and tumor necrosis factors and is formed by neutrophils and macrophages . CCL6 is also induced by interleukin 13 . The amino acids 21 to 95 and 22 to 95 show a chemotactic effect on lymphocytes , neutrophils, and monocytes . CCL6 binds to CCR1 . It is an inflammatory chemokine and strengthens the signaling pathways of ERK1 and ERK2 as well as the activity of GTPases . CCL6 has two disulfide bridges .
In cell cultures of bone marrow cells is amplified by stimulation with GM-CSF expressed . Furthermore, it is in the cell lines DA3 and 32D cl3 (myeloid cell line) and the macrophage cell line P388D expressed. Expression is greatly reduced in activated T cell lines . In mice, the gene is on chromosome 11.
Web links
Individual evidence
- ↑ a b Ma et al. The C10 / CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2004 Feb 1; 172 (3): 1872-81.
- ↑ Orlofsky et al. Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes. Cell Regul. 2 (5): 403-412 (1991).
- ↑ Berger et al. The gene for C10, a member of the beta-chemokine family, is located on mouse chromosome 11 and contains a novel second exon not found in other chemokines. DNA Cell Biol. 12 (9), 839-847 (1993)