COL9A2
Type IX collagen, alpha 2 | ||
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other names |
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Properties of human protein | ||
Mass / length primary structure | 689 amino acids , 65,131 Da | |
Identifier | ||
Gene names | COL9A2; DJ39G22.4, STL5, EDM2, MED | |
External IDs | ||
Occurrence | ||
Parent taxon | Euteleostomi | |
Orthologue | ||
human | House mouse | |
Entrez | 1298 | 12840 |
Ensemble | ENSG00000049089 | ENSMUSG00000028626 |
UniProt | Q14055 | Q07643 |
Refseq (mRNA) | NM_001852 | NM_007741 |
Refseq (protein) | NP_001843.1 | |
Gene locus | Chr 1: 40.3 - 40.32 Mb | Chr 4: 121.04 - 121.06 Mb |
PubMed search | 1298 |
12840
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Collagen type IX, alpha 2 is a fibrillenassoziiertes collagen that the gene COL9A2 is encoded. Together with the related collagen type IX, alpha 1 and collagen type IX, alpha 3, it forms heterotrimers , which in turn form collagen fibrils of type IX.
properties
Collagen type IX, alpha 2 is part of the hyaline cartilage and the vitreous body . What is special about this chain is that it contains glycosaminoglycans as a side chain. Because the glycosaminoglycans bind covalently to the protein in the form of proteoglycans , they give the fiber-forming substances a high degree of elasticity. The elasticity is due to the fact that glycosaminoglycans can absorb water.
Web links
Individual evidence
- ↑ Z. Zhang, J, Zhang, L. Ding, X. Teng: Meta-analysis of the association between COL9A2 genetic polymorphisms and lumbar disc disease susceptibility . In: Spine (Phila Pa 1976) . 39, No. 20, September 15, 2014, pp. 1699–1706. doi : 10.1097 / BRS.0000000000000497 . PMID 24983932 .
- ^ PN Bishop, M. Takanosu, M. le Goff, R. Mayne: The role of the posterior ciliary body in the biosynthesis of vitreous humor . In: Eye . 16, 2002, pp. 454-460. doi : 10.1038 / sj.eye.6700199 .
- ↑ Eva-Lena Stattin, Fredrik Wiklund, Karin Lindblom, Patrik Önnerfjord, Björn-Anders Jonsson, Yelverton Tegner, Takako Sasaki, André Struglics, Stefan Lohmander, Niklas Dahl, Dick Heinegård, Anders Aspberg: A Missense Mutation in the Aggrecan C-type Lectin Domain Disrupts Extracellular Matrix Interactions and Causes Dominant Familial Osteochondritis Dissecans . In: Am J Hum Genet . 86, No. 2, February 12, 2010, pp. 126-137. doi : 10.1016 / j.ajhg.2009.12.018 . PMC 2820178 (free full text).