CXCL4
| Platelet factor 4 | ||
|---|---|---|
| other names |
CXC motif chemokine 4, Iroplact, Oncostatin-A |
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| Properties of human protein | ||
| Mass / length primary structure | 101 amino acids , 10,845 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 5196 | |
| Ensemble | ENSG00000163737 | |
| UniProt | P02776 | |
| Refseq (mRNA) | NM_002619.3 | |
| Refseq (protein) | NP_002610.1 | |
| PubMed search |
5196
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Platelet factor 4 (synonym CXCL4 ) is a protein from the group of chemokines . As a chemokine, it is a surface protein and is involved in the immune response . The chemokine serves as a cellular warning signal. Immune cells with a suitable chemokine receptor bind to the chemokine , as a result of which immune cells accumulate at the site of inflammation and the immune response is strengthened locally. As a CXC chemokine, it has four cysteines , the first two of which have any amino acid X in between, followed by 24 amino acids up to the third cysteine and 15 amino acids between the third and fourth cysteines.
The protein is found in high concentrations in patients with scleroderma who also have interstitial lung disease .
literature
- Kenneth Murphy: Janeway's Immunobiology, 9th edition. Garland Science, 2016, ISBN 978-1-315-53324-7 , pp. 453-456. The 5th English edition is available online on the pages of the NCBI Bookshelf (online) .
- Zlatko Dembic: The Cytokines of the Immune System. Academic Press, 2015, ISBN 978-0-12-420010-4 , pp. 255-258.
- Frans P. Nijkamp: Principles of Immunopharmacology. Springer Science & Business Media, 2011, ISBN 978-3-0346-0136-8 , pp. 72-74.
- Dieter Adam: Infectiology. Springer-Verlag, 2013, ISBN 978-3-642-18577-9 , pp. 32–33.
Web links
Individual evidence
- ↑ Werner Luttmann: The Experimenter: Immunology. Springer-Verlag, 2014, ISBN 978-3-642-41899-0 , pp. 278-280.
- ^ Robert R. Rich: Clinical Immunology. Elsevier Health Sciences, 2012, ISBN 978-0-7234-3710-9 , pp. 136-140.
- ↑ Elizabeth R. Volkmann, Donald P. Tashkin, Michael D. Roth, Philip J. Clements, Dinesh Khanna, Daniel E. Furst, Maureen Mayes, Julio Charles, Chi-Hong Tseng, Robert M. Elashoff, Shervin Assassi: Changes in plasma CXCL4 levels are associated with improvements in lung function in patients receiving immunosuppressive therapy for systemic sclerosis-related interstitial lung disease . In: Arthritis Research & Therapy . tape 18 , December 30, 2016, pp. 305 , doi : 10.1186 / s13075-016-1203-y , PMID 28038680 , PMC 5203703 (free full text).