Interstitial lung disease

Classification according to ICD-10
J84.-	Other interstitial lung diseases
J68.4	Pulmonary fibrosis (chronic): from inhalation of chemicals, gases, smoke, vapors
ICD-10 online (WHO version 2019)

Interstitial lung disease (English: I nterstitial L ung D isease ( ILD )) or diffuse parenchymal lung (English: D iffuse P arenchymal L ung D isease ( DPLD )) refers to a group of lung diseases which the epithelium of the alveoli (alveolar), the endothelium of the lungs is affected by capillaries , the basement membrane and the perivascular and perilymphatic tissues of the lungs. The designation as interstitial disease (" I LD") distinguishes these clinical pictures from obstructive airway diseases (such as COPD ). Most types of this condition are associated with fibrosis ( diffuse progressive interstitial pulmonary fibrosis ; see also acute interstitial pneumonia ), which, however, can develop later.

classification

ILD without a known underlying disease

Idiopathic interstitial pneumonia (IIP)

ILD with known cause

• Many drugs, especially immunologically active drugs, can cause ILD

• Pneumoconiosis : aluminosis , stannosis , silicosis , asbestosis , berylliosis , siderosis , anthracosis , hard metal fibrosis

• Extrinsic allergic alveolitis : farmer's lung , bird fancier's lung , Malzarbeiterlunge , detergent lung , Befeuchterlunge , grain weevils lung , isocyanate alveolitis

• Allergic bronchopulmonary aspergillosis

• Adult Respiratory Distress Syndrome (ARDS)

• Aspiration pneumonia

• Radiation pneumonitis

• Collagenoses : systemic lupus erythematosus , rheumatoid arthritis , ankylosing spondylarthritis , systemic sclerosis , Sjogren's syndrome , polymyositis , dermatomyositis , scleroderma , CREST syndrome

• Vasculitis : granulomatosis with polyangiitis , polyarteritis nodosa , eosinophilic granulomatosis with polyangiitis ( Churg-Strauss syndrome )

• Pulmonary hemorrhage syndromes : Goodpasture syndrome , idiopathic pulmonary hemosiderosis , Ceelen-Gellerstedt syndrome , isolated pulmonary capillary inflammation

• Alveolar proteinosis

• Carcinomatous lymphangitis

• Eosinophilic pneumonia

• Lymphangioleiomyomatosis

• Amyloidosis

• Hereditary diseases : tuberous sclerosis , neurofibromatosis , Niemann-Pick syndrome , Gaucher's disease , Hermansky-Pudlak syndrome

• Langerhans cell histiocytosis

• Granulomatous vasculitis

• chronic active hepatitis , primary biliary cholangitis , Crohn's disease , ulcerative colitis , Whipple's disease (diseases of the liver and gastrointestinal tract)

• Graft-versus-Host-Disease (GvHD)

• Sarcoid

Clinical picture

The interstitial lung diseases show a very variable clinical picture. Mostly a restrictive ventilation disorder can be recognized, the patients complain above all of shortness of breath during exertion. The diffusion capacity is often reduced; if the course is unfavorable, respiratory insufficiency , pulmonary hypertension and cor pulmonale develop .

Individual evidence

1. ↑ Joachim Frey : Diseases of the respiratory organs. In: Ludwig Heilmeyer (ed.): Textbook of internal medicine. Springer-Verlag, Berlin / Göttingen / Heidelberg 1955; 2nd edition, ibid. 1961, pp. 599-746, here: p. 708.
2. ↑ Berdel V. et al. [Ed.]; Diehl Classen: Internal Medicine . Urban & Fischer in Elsevier, Munich 2006, ISBN 978-3-437-44405-0
3. ↑ ^{a b c} Poletti V et al .: Rare infiltrative lung diseases: a challenge for clinicians. Respiration. 2004 Sep-Oct; 71 (5): 431-43 PMID 15467318
4. ^ Renz-Polster et all (2008) basic textbook internal medicine. Elsevier GmbH: Munich.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !