Aluminosis
| Classification according to ICD-10 | |
|---|---|
| J63 | Pneumoconiosis due to other inorganic dusts |
| J63.0 | Aluminosis (lungs) |
| ICD-10 online (WHO version 2019) | |
Under a aluminosis (also bauxite workers' disease ) refers to pathological changes in the lung caused by chronic exposure over alumina smoke arise or dust. Aluminosis is a pneumoconiosis and is an occupational disease that is subject to compensation .
Pathophysiology
The aluminum oxide particles interact directly with the cell membranes of the lung tissue. After their deposition in the alveoli (alveoli), the particles result in increased fibroblast activity and thus to gradual tissue remodeling of the parenchyma of the lung. The risk increases with the increase in the respirable portion of the dust fraction and with the exposure time.
course
With a latency of around 10–20 years, the inhalation of aluminum oxide dust leads to progressive, diffuse interstitial pulmonary fibrosis with a tendency to shrink. The extent of the disease varies greatly from person to person. The aluminosis often ends in a restrictive ventilation disorder . Bronchial carcinoma (lung cancer) is one of the long-term consequences .
literature
- Joachim Lorenz: Checklist XXL Pneumology: 132 tables; [Incl. CD-ROM] . Thieme, Stuttgart / New York 2003, ISBN 3-13-115072-6 .
Individual evidence
- ↑ T. Kraus, KH Schaller, J. Angerer, RD Hilgers, S. Letzel: Aluminosis - detection of an almost forgotten disease with HRCT . In: Journal of Occupational Medicine and Toxicology (London, England) . tape 1 , 2006, p. 4 , doi : 10.1186 / 1745-6673-1-4 , PMID 16722569 , PMC 1436008 (free full text).
Web links
- Aluminum, aluminum silicates, aluminum Alzheimer's myth (accessed July 17, 2020)
- Aluminum toxicology and health aspects of body-related applications (accessed on July 17, 2020)
- Characterization of the rat macrophage cell lines R2 and NR8383 and investigation of the influence of selected mineral fibers and particles on the release of immunologically active substances (accessed on July 17, 2020)
- Leaflet on occupational disease number 4106 Diseases of the deeper airways and lungs caused by aluminum and its compounds (accessed on July 17, 2020)
- Aluminum dust lung from aluminum welding Unusual disease progression and possible causes (accessed on July 17, 2020)
| This text is based in whole or in part on the entry Aluminose in Flexikon , a wiki from DocCheck . The takeover took place on July 20, 2009 under the then valid GNU license for free documentation . |