Calnexin
| Calnexin | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 572 amino acids | |
| Secondary to quaternary structure | single pass membrane protein | |
| Cofactor | Ca 2+ | |
| Identifier | ||
| Gene name | CANX | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Eukaryotes | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 821 | 12330 |
| Ensemble | ENSG00000127022 | ENSMUSG00000020368 |
| UniProt | P27824 | P35564 |
| Refseq (mRNA) | NM_001024649 | NM_001110499 |
| Refseq (protein) | NP_001019820 | NP_001103969 |
| Gene locus | Chr 5: 179.68 - 179.73 Mb | Chr 11: 50.29 - 50.33 Mb |
| PubMed search | 821 |
12330
|
Like its homolog calreticulin, calnexin is a lectin of the endoplasmic reticulum (ER). Calnexin can already be found in the simplest eukaryotes . It is one of the chaperones .
It is membrane-bound (in contrast to soluble calreticulin). The activity of both proteins depends on calcium ions, which are present in high concentrations in the ER . Calnexin and calreticulin both recognize certain sugar residues from incompletely folded proteins and support them in their folding process .
literature
- R. Benyair, E. Ron, GZ Lederkremer: protein quality control, retention and degradation at the endoplasmic reticulum. In: Int Rev Cell Mol Biol. 292, 2011, pp. 197-280. doi: 10.1016 / B978-0-12-386033-0.00005-0 . PMID 22078962 .
- LEV Del Bem: The evolutionary history of calreticulin and calnexin genes in green plants. In: Genetica. 139 (2), 2011, pp. 225-229. doi: 10.1007 / s10709-010-9544-y . PMID 21222018 .
- B. Kleizen, I. Braakman: Protein folding and quality control in the endoplasmic reticulum. In: Curr. Opin. Cell Biol. 16 (4), 2005, pp. 343-349. doi: 10.1016 / j.ceb.2004.06.012 . PMID 15261665 .
- Jeremy M. Berg, John L. Tymoczko, Lubert Stryer : Biochemistry. 6th edition. Spectrum Akademischer Verlag, Heidelberg 2007, ISBN 978-3-8274-1800-5 .
- Donald Voet, Judith G. Voet: Biochemistry. 3. Edition. John Wiley & Sons, New York 2004, ISBN 0-471-19350-X .
- Bruce Alberts , Alexander Johnson, Peter Walter, Julian Lewis, Martin Raff, Keith Roberts: Molecular Biology of the Cell. 5th edition. Taylor & Francis, 2007, ISBN 978-0-8153-4106-2 .