Carl-Philipp Heisenberg
Carl-Philipp Heisenberg (* 1968 in Munich ) is a German developmental biologist ( embryology , cell biology ).
Life
Heisenberg is a grandson of Werner Heisenberg . The neurobiologist Martin Heisenberg is his uncle. He studied biology in Munich (diploma 1992), Cambridge (master’s degree 1995) and Tübingen (doctorate 1997, with Christiane Nüsslein-Volhard ) and was a post-doctoral student at University College London. From 2001 he was at the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden as a research group leader and Emmy Noether junior professor.
He has been a professor and group leader at the Institute of Science and Technology Austria (IST Austria) since 2010 .
He researches the regulation in the early stages of embryonic development ( blastulation , gastrulation ) of zebrafish as model animals. Among other things, he was able to explain the mechanism of epibolism in blastulation. The dividing embryonic cells grow along a ring over the yolk cell (doming), this consists of actomyosin network and contracts with its internal tension in a spherical shape and is previously propelled in the expansion by a contraction tension acting perpendicular to the ring tension. They were also able to elucidate physical mechanisms in the cells that play a role in the arrangement in cell associations (later organs) (adhesion between cells of the same type). The role of cadherines had been known for a long time. Heisenberg and his group also found that a supporting structure (cortex) made of actomyosin on the cell surface plays an important role. If its voltage drops (which is actively controlled by the cells), the contact area and thus the adhesion is greater. This also plays a role, for example, in the formation of metastases in cancer.
He also found a role of mechanical forces such as friction in the formation of the neural plate and investigated the interaction of gene regulatory networks and physical influences in embryonic development and especially gastrulation.
In 2015 he became a member of the Leopoldina . In 2016 he became a member of the European Molecular Biology Organization (EMBO) and in 2017 he received an ERC Advanced Grant and the Science Prize of the State of Lower Austria . For 2019, Heisenberg was awarded the Carus Medal of the Leopoldina.
Fonts (selection)
In addition to the works cited in the footnotes:
- with M. Smutny and others: Friction forces position the neural anlage, Nature Cell Biology, Volume 9, 2017, pp. 306-317.
- with V. Ruprecht et al .: Cortical contractility triggers a stochastic switch to fast amoeboid cell motility, Cell, Volume 160, 2015, pp. 673–685.
Awards
- Carus Medal (2019)
Web links
Individual evidence
- ↑ Kurt de Swaaf, What Fish and Humans Have in Common , Der Standard, November 7, 2012
- ↑ Maitre, Heisenberg et al., Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells, Science, Volume 338, pp. 253-256.
- ↑ Behrndt, Heisenberg et al., Forces driving epithelial spreading in zebrafish gastrulation, Science, Volume 338, pp. 257-260.
- ↑ Member entry by Prof. Dr. Carl-Philipp Heisenberg (with picture and CV) at the German Academy of Natural Scientists Leopoldina , accessed on July 20, 2017.
- ↑ IST professor receives German Carus medal on ORF on September 9, 2019, accessed on September 9, 2019
personal data | |
---|---|
SURNAME | Heisenberg, Carl-Philipp |
BRIEF DESCRIPTION | German developmental biologist |
DATE OF BIRTH | 1968 |
PLACE OF BIRTH | Munich |