Carlos Barbas

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Carlos F. Barbas III ( November 5, 1964 - June 24, 2014 ) was an American chemist . He was a professor at the Skaggs Institute of Biological Chemistry and Scripps Research Institute (Janet and W. Keith Kellogg II. Professorship in Molecular Biology).

Life

Barbas received his bachelor's degrees in chemistry and physics from Eckerd College in 1985, received her PhD in organic chemistry from Texas A&M University with Chi-Huey Wong in 1989 , and was a post-doctoral student with Richard Lerner and Steven Benkovic at the Scripps Research Institute and the University of Pennsylvania . In 1991 he became Assistant Professor, 1995 Associate Professor and 1997 Professor at the Scripps Research Institute in the Department of Molecular Biology.

Barbas was a leading scientist in organic catalysis and especially asymmetric catalysis at the intersection of chemistry, biology and medicine. He was involved in the development of new drugs, synthetic antibodies and vaccines, for example for cancer therapy and HIV.

He developed a method to configure zinc finger proteins specifically as transcription factors. The method has multiple applications in the development of new drugs.

With Kandasamy Sakthivel , he developed modified forms of DNA in 1998, which provide more leeway in the development of DNA enzymes, but which can still be replicated using PCR .

He also developed a new, simple synthesis route for pharmaceutically interesting amino acids (for example for beta-lactam antibiotics or protease blockers in HIV ) using the amino acid L-proline. The synthesis is enantiomer-selective .

He was the founder of CovX Pharmaceuticals and Zyngenia Inc. and a co-founder of Prolifaron Inc.

Since 1992 he has led the Phage Display of Proteins and Peptids course at the Cold Spring Harbor Laboratory.

He received the Arthur C. Cope Scholar Award and in 2009 the Tetrahedon Young Investigator Award in Bioorganic and Medicinal Chemistry. From 1992 to 1995 he was a scholar at the American Foundation for Aids Research. From 2003 he was one of the ISI Highly Cited Researchers .

Barbas died on June 24, 2014 of complications from a rare form of thyroid cancer.

Fonts

  • with RR Beerli: Engineering Polydactyl Zinc Finger Transcription Factors. Nature Biotechnology, 20, 2002, p. 135
  • with D. Shabat, HN Lode, U. Pertl, RA Reisfeld, C. Rader, RA Lerner: In vivo activity in a catalytic antibody-prodrug system: antibody catalyzed etoposide prodrug activation for selective chemotherapy. Proc. Natl. Acad. Sci. USA, 98, 2001, p. 7528
  • with W. Notz, F. Tanaka: Enamine-based organocatalysis with proline and diamines: The development of Direct Catalytic Asymmetric Aldol, Mannich, Michael, and Diels-Alder Reactions, Accounts of Chemical Research, 37, 2004, 580-591.
  • with C. Rader, SC Sinha, M. Popkov, RA Lerner: Chemically programmed monoclonal antibodies for cancer therapy: Adapter immunotherapy based on a covalent antibody catalyst. Proc. Nat. Acad. Sci. USA, 100, 2003, pp. 5396-5400.

Web links

Individual evidence

  1. ^ Obituary, Chemistry News .
  2. ^ Biographical data, publications and academic family tree of Carlos F. Barbas at academictree.org, accessed on January 6, 2018.
  3. ↑ Software for the Genome Created by Scientists at The Scripps Research Institute, Press Release, Scripps Research Institute 2000 ( Memento of the original dated November 24, 2012 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. . @1@ 2Template: Webachiv / IABot / www.scripps.edu
  4. ↑ Kandasamy Sakthivel, Carlos F. Barbas: Extension of the binding and catalysis properties of DNA: highly functionalized dUTP derivatives as substrates for thermostable DNA polymerases. In: Angewandte Chemie. 110, 1998, pp. 2998-3002, doi : 10.1002 / (SICI) 1521-3757 (19981016) 110: 20 <2998 :: AID-ANGE2998> 3.0.CO; 2-L .
  5. ↑ When Four Letters Are Not Enough: Chemists expand the DNA alphabet in order to build protein-like DNA enzymes, Press Release, Scripps Research Institute 1998 ( Memento of the original from November 24, 2012 in the Internet Archive ) Info: The archive link was inserted automatically and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. . @1@ 2Template: Webachiv / IABot / www.scripps.edu
  6. ^ Jason Bardi Catalysis made easy , Scripps Research Institute 2002 .
  7. ^ Scripps Institute: In Memoriam: Carlos F. Barbas III (1964-2014) .
personal data
SURNAME Barbas, Carlos
ALTERNATIVE NAMES Barbas, Carlos F.
BRIEF DESCRIPTION American chemist
DATE OF BIRTH 5th November 1964
DATE OF DEATH June 24, 2014