Granulomatous cheilitis

from Wikipedia, the free encyclopedia
Classification according to ICD-10
G51.2 Melkersson-Rosenthal syndrome
ICD-10 online (WHO version 2019)

The granulomatous cheilitis is a rare disease with persistent swelling of the lips based on a granulomatous inflammation .

It is regarded as a subtype of orofacial granulomatosis .

Synonyms are: granulomatose orofaciale; OFG; Orofacial granulomatosis; granulomatous macrochyllium; Miescher cheilitis; english granulomatous cheilitis

The first description comes from 1945 by the Swiss dermatologist Alfred Guido Miescher (1887–1961).

distribution

The frequency is given as 0.08%.

root cause

The cause is not known.

The disease can occur idiopathically  or as a skin manifestation in a granulomatous systemic disease such as Melkersson-Rosenthal syndrome , sarcoid or Crohn's disease (especially in children), but also in the context of food allergies .

Clinical manifestations

Clinical criteria are:

  • Manifestation usually between the ages of 20 and 40, both sexes are affected equally often.

It is a disfiguring, initially recurring, then persistent granuloma-forming swelling of the lips.

diagnosis

The diagnosis is based on clinical findings.

The following must be distinguished from the differential diagnosis:

literature

  • T. Jansen, S. Grabbe: Therapy of cheilitis granulomatosa with fumaric acid esters: results of a prospective uncontrolled study , In:

Akta Dermatologica 2007; Vol. 33, pp. 72-75, [1]

  • WA Critchlow, D. Chang: Granulomatous cheilitis: a review. In: Head and neck pathology. Volume 8, number 2, June 2014, pp. 209-213, doi: 10.1007 / s12105-013-0488-2 , PMID 24057987 , PMC 4022933 (free full text) (review).
  • R. Wadhawan, PR Singh Khurana, N. Khanduri, G. Solanki. Unveiling the Curtain on Orofacial Granulomatosis: An Overview. In: Acta Biomedica Scientia. 2015. Vol. 2, No. 3, pp. 148–151
  • R. Miest, A. Bruce, RS Rogers: Orofacial granulomatosis. In: Clinics in dermatology. Volume 34, number 4, 2016 Jul – Aug, pp. 505-513, doi: 10.1016 / j.clindermatol.2016.02.024 , PMID 27343966 .

Individual evidence

  1. ↑ a b c d Encyclopedia Dermatology
  2. ↑ Entry on Cheilitis_granulomatosa in Flexikon , a Wiki of the DocCheck company
  3. ↑ a b emedicine
  4. ↑ Who named it
  5. ↑ G. Miescher: About essential granulomatous macrocheilia (cheilitis granulomatosa) . In: Dermatologica 1945; Vol. 91, pp. 57-85