Chondroblast

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The chondroblast (from the Greek chondros "granule", "cartilage" and blastos "germ", "sprout") is a cell type that is capable of forming (→ blast ) cartilage tissue (chondrogenesis).

Function and cycle

Chondroblasts are derived from mesenchymal stem cells . They produce all the components of the basic cartilage substance (cartilage matrix) such as type II collagen and glycosaminoglycans (especially chondroitin sulfate , keratan sulfate and hyaluronic acid ) and release them into the environment. Due to the continuous formation of this extracellular matrix, they separate from their neighboring cells and come to lie in closed cavities (lacunae). When matrix synthesis ceases and the ability to divide, they differentiate into chondrocytes , the actual cartilage cells.

The fibroblast growth factor-18 (FGF-18) stimulates in model organisms for intra-articular injection, the formation of cartilage at. A recombinantly produced human FGF-18 is currently in clinical trials for the treatment of osteoarthritis.

See also

literature

  • Abraham L. Kierszenbaum: Histology and cell biology: an introduction to pathology . Elsevier Health Sciences, 2002, ISBN 978-0-323-01639-1

Web links

Wiktionary: Chondroblast  - explanations of meanings, word origins, synonyms, translations

Individual evidence

  1. ↑ EE Moore, AM Bendele, DL Thompson, A. Littau, KS Waggie, B. Reardon, JL Ellsworth: Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. In: Osteoarthritis and Cartilage Volume 13, Number 7, July 2005, pp. 623-631, ISSN  1063-4584 . doi : 10.1016 / j.joca.2005.03.003 . PMID 15896984 .
  2. ↑ D. Davidson, A. Blanc, D. Filion, H. Wang, P. Plut, G. Pfeffer, MD Buschmann, JE Henderson: Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. In: Journal of Biological Chemistry Volume 280, Number 21, May 2005, pp. 20509-20515, ISSN  0021-9258 . doi : 10.1074 / jbc.M410148200 . PMID 15781473 .
  3. ↑ clinicaltrials.gov: Study of AS902330 (rhFGF-18) Administered Intra-articularly in Patients With Knee Primary Osteoarthritis Who Are Candidates for Total Knee Replacement. Retrieved January 30, 2011.
  4. ↑ clinicaltrials.gov: A Multicenter Study of rhFGF 18 in Patients With Knee Osteoarthritis Not Requiring Surgery. Retrieved January 30, 2011.