Clemens Steegborn

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Clemens Johannes Steegborn (born September 23, 1971 in Karlsruhe ) is a German biochemist and professor of biochemistry who researches the molecular mechanisms of aging processes and their modulation with active ingredients.

Life

Steegborn studied biochemistry at the University of Bayreuth and received his doctorate summa cum laude with Nobel laureate Robert Huber at the Max Planck Institute for Biochemistry in Martinsried. Steegborn did research as a postdoc with Hao Wu at Cornell Medical College (NY, USA) and as a junior professor at the Ruhr University in Bochum . Since 2010 he has headed the Department of Biochemistry at the University of Bayreuth. He is Deputy Managing Director of the Institute for Biomacromolecules (BioMac) at the University of Bayreuth and was co-speaker of the study group "Structural Research" of the Society for Biochemistry and Molecular Biology .

research

Steegborn investigates molecular mechanisms of signal transmission in cells that are involved in aging processes and aging-associated diseases. The focus is on the function, regulation and pharmacological modulation of NAD + -dependent deacylases (sirtuins) and the bicarbonate-activated soluble adenylyl cyclase. As a result of their regulation, these enzymes act as sensors for the cell's energy metabolism, which is closely linked to aging processes, and are suitable as active substance targets for diseases associated with aging.

Awards

Individual evidence

  1. ↑ a b http://www.biochemie.uni-bayreuth.de/de/team/Steegborn_Clemens/index.php
  2. ↑ a b H. Dai, DA Sinclair et al. a .: Sirtuin activators and inhibitors: Promises, achievements, and challenges. In: Pharmacology & therapeutics. Volume 188, August 2018, pp. 140-154, doi : 10.1016 / j.pharmthera.2018.03.004 , PMID 29577959 (review).
  3. ↑ a b C. Steegborn: Structure, mechanism, and regulation of soluble adenylyl cyclases - similarities and differences to transmembrane adenylyl cyclases. In: Biochimica et Biophysica Acta . Volume 1842, number 12 Pt B, December 2014, pp. 2535-2547, doi : 10.1016 / j.bbadis.2014.08.012 , PMID 25193033 (review).
  4. ↑ M. Lakshminarasimhan, C. Steegborn: Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets. In: Experimental Gerontology. Volume 46, number 2-3, 2011, pp. 174-177, doi : 10.1016 / j.exger.2010.08.024 , PMID 20849945 (review).
  5. ^ EF Fang, S. Lautrup u. a .: NAD in Aging: Molecular Mechanisms and Translational Implications. In: Trends in Molecular Medicine. Volume 23, number 10, 10 2017, pp. 899-916, doi : 10.1016 / j.molmed.2017.08.001 , PMID 28899755 (review).
  6. ↑ The Sirtuin 2 Enzyme and Alzheimer's Disease. Retrieved May 17, 2018 .
personal data
SURNAME Steegborn, Clemens
ALTERNATIVE NAMES Steegborn, Clemens Johannes (full name)
BRIEF DESCRIPTION German biochemist and professor of biochemistry
DATE OF BIRTH 23rd September 1971
PLACE OF BIRTH Karlsruhe