D-like heterogeneous nuclear ribonucleoprotein
| D-like heterogeneous nuclear ribonucleoprotein | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 420 AA | |
| Isoforms | 3 | |
| Identifier | ||
| Gene names | HNRNPDL HNRPDL, JKTBP, laAUF1 | |
| External IDs | ||
The D-like heterogeneous nuclear ribonucleoprotein ( English heterogeneous nuclear ribonucleoprotein D-like , short hnRNP D-like or hnRNP DL ) is a protein found in eukaryotes . It can be found in the nucleus and cytoplasm of most eukaryotic cells. In humans, it is encoded by the HNRNPDL gene and is located on the long arm of chromosome 4 (4q21.22).
The protein is involved in the regulation of transcription and has binding sites for certain DNA and RNA sequences . Mutations in the HNRNPDL gene can cause girdle dystrophy 1G .
literature
- NM Vieira, MS Naslavsky et al. a .: A defect in the RNA-processing protein HNRPDL causes limb-girdle muscular dystrophy 1G (LGMD1G). In: Human Molecular Genetics . [Electronic publication before printing] March 2014, ISSN 1460-2083 , doi : 10.1093 / hmg / ddu127 , PMID 24647604 .
- DJ Omnus, S. Mehrtens u. a .: JKTBP1 is involved in stabilization and IRES-dependent translation of NRF mRNAs by binding to 5 'and 3' untranslated regions. In: Journal of molecular biology. Volume 407, number 4, April 2011, ISSN 1089-8638 , pp. 492-504, doi : 10.1016 / j.jmb.2011.01.050 , PMID 21300069 .
- D. Kamei, N. Tsuchiya, et al. a .: Two forms of expression and genomic structure of the human heterogeneous nuclear ribonucleoprotein D-like JKTBP gene (HNRPDL). In: Genes. Volume 228, Number 1-2, March 1999, ISSN 0378-1119 , pp. 13-22, PMID 10072754 .