DADLE

Structural formula
General
Surname	DADLE
other names	[ D -Ala 2 , D -Leu 5 ] -enkephalin L -Tyrosyl- D -alanylglycyl- L -phenylalanyl- D -leucine N - ( N - ( N - ( N - L -tyrosyl- D -alanyl) glycyl) - L -phenylalanyl) - D -leucine Tyr- D -Ala-Gly-Phe- D- Leu-OH
Molecular formula	C 29 H 39 N 5 O 7
External identifiers / databases
CAS number 64963-01-5 EC number 265-291-0 ECHA InfoCard 100.059.337 PubChem 6917707 Wikidata Q424905
properties
Molar mass	569.65 g mol −1
safety instructions
GHS hazard labeling no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

DADLE ([ D - A la ² , D - L eu ⁵ ] - E nkephalin ) is a synthetic opioid peptide with analgesic ( analgesic ) properties.

The peptide sequence is Tyr- D -Ala-Gly-Phe- D -Leu.

Although partially described as a selective agonist on the δ opioid receptor , DADLE also acts agonistically on the μ ₁ opioid receptor. In addition to analgesia, the substance causes a temporary decrease in arterial blood pressure and heart rate . With ground squirrels, DADLE is able to induce hibernation in summer . DADLE also increases the survival time of explanted organs such as the liver and lungs.

Web links

• DADLE in the IUPHAR database.

Individual evidence

1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
2. ↑ ^{a b} Leucine-2-Alanine Enkephalin in the Medical Dictionary Online.
3. ↑ L. Vecchio et al .: DADLE induces a reversible hibernation-like state in HeLa cells . In: Histochemistry and Cell Biology, Volume 125, Numbers 1-2, 193-201, doi : 10.1007 / s00418-005-0085-x