DIRAS3
| GTP binding protein Di-Ras3 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 25,861 daltons / 229 amino acids | |
| Identifier | ||
| Gene names | DIRAS3 ARHI, NOEY2, RHOI | |
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 9077 | |
| Ensemble | ENSG00000162595 | |
| UniProt | O95661 | |
| Refseq (mRNA) | NM_004675 | |
| Refseq (protein) | NP_004666 | |
| Gene locus | Chr 1: 68.05 - 68.05 Mb | |
| PubMed search |
9077
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The GTP binding protein Di-Ras3 is a protein encoded by the DIRAS3 gene . It belongs to the proteins around the Ras family and is to be understood as a tumor suppressor that has lost its function, particularly in breast cancer and ovarian cancer . This is where DIRAS3 is most strongly expressed in healthy tissue ; expression in other tissues differs. The protein has a highly conserved GTP-binding domain , probably an effector domain that differs significantly from those of the Ras and Rap proteins, and a C -terminal motif for membrane localization .