Homeobox protein DLX-4

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Homeobox protein DLX-4
Properties of human protein
Mass / length primary structure 240 amino acids
Isoforms 3
Identifier
Gene name DLX4
External IDs
Occurrence
Parent taxon Mammals

The homeobox protein DLX4 is a protein for which the existing in people DLX4 - gene coded.

function

Many vertebrate genes containing Homeobox have been identified on the basis of the similarity of their sequence to the developmental genes of Drosophila . Members of the Dlx gene family contain a homeobox that is related to the "distal-less" (Dll), a gene that is expressed in the head and limbs of a developing fruit fly. The “Distal-less” gene family (Dlx) comprises at least six different members, DLX1 - DLX6 . The DLX proteins have a role in the forebrain and in the development of the facial skull. Three transcription variants for this gene have already been shown, but the full length of one of these variants has not. Studies of the two splice variants showed that one of the encoded isoforms acts as a repressor of the β-globin gene, while the other isoform lacks this function.

Individual evidence

  1. ↑ Orthologist at OMA
  2. ↑ a b Entrez Gene: DLX4 distal-less homeobox 4 . Retrieved May 20, 2012.

Web links

literature

  • S. Nakamura, DW Stock, KL Wydner, JA Bollekens, K. Takeshita, BM Nagai, S. Chiba, T. Kitamura, TM Freeland, Z. Zhao, J. Minowada, JB Lawrence, KM Weiss, FH Ruddle: Genomic analysis of a new mammalian distal-less gene: Dlx7. In: Genomics. Volume 38, Number 3, December 1996, ISSN  0888-7543 , pp. 314-324, doi : 10.1006 / geno.1996.0634 . PMID 8975708 .
  • LM Quinn, BV Johnson, J. Nicholl, GR Sutherland, B. Kalionis: Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4. In: Genes. Volume 187, Number 1, March 1997, ISSN  0378-1119 , pp. 55-61, doi : 10.1016 / S0378-1119 (96) 00706-8 , PMID 9073066 .
  • MI Morasso, R. Yonescu, CA Griffin, TD Sargent: Localization of human DLX8 to chromosome 17q21.3-q22 by fluorescence in situ hybridization. In: Mammalian genome: official journal of the International Mammalian Genome Society. Volume 8, Number 4, April 1997, ISSN  0938-8990 , pp. 302-303, doi : 10.1007 / s003359900427 , PMID 9096128 .
  • JA Price, DW Bowden, JT Wright, MJ Pettenati, TC Hart: Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome. In: Human Molecular Genetics . Volume 7, number 3, March 1998, ISSN  0964-6906 , pp. 563-569, doi : 10.1093 / hmg / 7.3.563 , PMID 9467018 .
  • LM Quinn, SE Latham, B. Kalionis: A distal-less class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta. In: Placenta. Volume 19, Number 1, January 1998, ISSN  0143-4004 , pp. 87-93, doi : 10.1016 / S0143-4004 (98) 90103-5 , PMID 9481790 .
  • LM Quinn, LM Kilpatrick, SE Latham, B. Kalionis: Homeobox genes DLX4 and HB24 are expressed in regions of epithelial-mesenchymal cell interaction in the adult human endometrium. In: Molecular human reproduction. Volume 4, Number 5, May 1998, ISSN  1360-9947 , pp. 497-501, doi : 10.1093 / molehr / 4.5.497 , PMID 9665637 .
  • LM Quinn, SE Latham, B. Kalionis: The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta. In: Placenta. Volume 21 Suppl A, 2000 Mar-Apr, ISSN  0143-4004 , pp. S50-S54, doi : 10.1053 / plac . 1999.0514 , PMID 10831122 .
  • SB Haga, S. Fu, JE Karp, DD Ross, DM Williams, WD Hankins, F. Behm, FW Ruscetti, M. Chang, BD Smith, D. Becton, SC Raimondi, PE Berg: BP1, a new homeobox gene, is frequently expressed in acute leukemias. In: Leukemia. Volume 14, Number 11, November 2000, ISSN  0887-6924 , pp. 1867-1875, doi : 10.1038 / sj.leu.2401912 , PMID 11069021 .
  • Y. Masuda, A. Sasaki, H. Shibuya, N. Ueno, K. Ikeda, K. Watanabe: Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function. In: The Journal of biological chemistry. Volume 276, Number 7, February 2001, ISSN  0021-9258 , pp. 5331-5338, doi : 10.1074 / jbc.M008590200 . PMID 11084035 .
  • S. Fu, H. Stevenson, JW Strovel, SB Haga, J. Stamberg, K. Do, PE Berg: Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. In: Genes. Volume 278, Number 1-2, October 2001, ISSN  0378-1119 , pp. 131-139, doi : 10.1016 / S0378-1119 (01) 00716-8 , PMID 11707330 .
  • K. Sumiyama, SQ Irvine, DW Stock, KM Weiss, K. Kawasaki, N. Shimizu, CS Shashikant, W. Miller, FH Ruddle: Genomic structure and functional control of the Dlx3-7 bigene cluster. In: Proceedings of the National Academy of Sciences . Volume 99, Number 2, January 2002, ISSN  0027-8424 , pp. 780-785, doi : 10.1073 / pnas.012584999 . PMID 11792834 , PMC 117382 (free full text).
  • MB Chase, S. Fu, SB Haga, G. Davenport, H. Stevenson, K. Do, D. Morgan, AL Mah, PE Berg: BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. In: Molecular and cellular biology. Volume 22, number 8, April 2002, ISSN  0270-7306 , pp. 2505-2514, doi : 10.1128 / MCB.22.8.2505-2514.2002 , PMID 11909945 , PMC 133721 (free full text).
  • RL Strausberg, EA Feingold, et al .: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. In: Proceedings of the National Academy of Sciences . Volume 99, Number 26, December 2002, ISSN  0027-8424 , pp. 16899-16903, doi : 10.1073 / pnas.242603899 . PMID 12477932 , PMC 139241 (free full text).
  • PJ Neufing, B. Kalionis, DJ Horsfall, C. Ricciardelli, J. Stahl, S. Vivekanandan, W. Raymond, WD Tilley: Expression and localization of homeodomain proteins DLX4 / HB9 in normal and malignant human breast tissues. In: Anticancer Research . Volume 23, Number 2B, 2003 Mar-Apr, ISSN  0250-7005 , pp. 1479-1488, PMID 12820413 .
  • OP Zoueva, GP Rodgers: Inhibition of beta protein 1 expression enhances beta-globin promoter activity and beta-globin mRNA levels in the human erythroleukemia (K562) cell line. In: Experimental hematology. Volume 32, number 8, August 2004, ISSN  0301-472X , pp. 700-708, doi : 10.1016 / j.exphem.2004.05.024 . PMID 15308321 .
  • DS Gerhard, L. Wagner, et al .: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). In: Genome research. Volume 14, number 10B, October 2004, ISSN  1088-9051 , pp. 2121-2127, doi : 10.1101 / gr.2596504 . PMID 15489334 , PMC 528928 (free full text).
  • MS Mpollo, M. Beaudoin, PE Berg, H. Beauchemin, V. D'Agati, M. Trudel: BP1 is a negative modulator of definitive erythropoiesis. In: Nucleic acids research. Volume 34, Number 18, 2006, ISSN  1362-4962 , pp. 5232-5237, doi : 10.1093 / nar / gkl680 . PMID 17003054 , PMC 1636446 (free full text).
  • P. Murthi, JM Said, VL Doherty, S. Donath, CJ Nowell, SP Brennecke, B. Kalionis: Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction. In: Molecular human reproduction. Volume 12, Number 12, December 2006, ISSN  1360-9947 , pp. 763-769, doi : 10.1093 / molehr / gal087 . PMID 17062780 .
  • S. Tomida, K. Yanagisawa, K. Koshikawa, Y. Yatabe, T. Mitsudomi, H. Osada, T. Takahashi: Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach. In: Oncogene. Volume 26, Number 31, July 2007, ISSN  0950-9232 , pp. 4600-4608, doi : 10.1038 / sj.onc.1210242 . PMID 17260014 .