DSE / DSI

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In neurophysiology, the abbreviation DSE stands for the term depolarization-induced suppression of excitation (English for "depolarization -induced suppression of excitation "). Similarly, DSI means depolarization-induced suppression of inhibition , ie “depolarization -induced suppression of inhibition”.

These terms describe the phenomenon that a depolarization of the postsynaptic neuron at synapses leads to a reduction in the release of neurotransmitters at the presynaptic terminal . In the case of DSE it is the excitatory transmitter glutamate , in the case of DSI it is the inhibitory transmitter GABA .

The mechanism of DSE or DSI is the following: The post-synaptic depolarization leads to an influx of calcium - ion by activation of voltage-activated calcium channels . This leads to a postsynaptic release of endocannabinoids . Retrograde activates these presynaptic endocannabinoid receptors (in the brain CB1), which leads to a reduction in the release of neurotransmitters, probably through the inhibition of presynaptic calcium channels.

DSI was first discovered in pyramidal cells in the hippocampus , DSE in Purkinje cells in the cerebellum . Today we know that neither DSI nor DSE are limited to these cell types in the brain.

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