DSE / DSI
In neurophysiology, the abbreviation DSE stands for the term depolarization-induced suppression of excitation (English for "depolarization -induced suppression of excitation "). Similarly, DSI means depolarization-induced suppression of inhibition , ie “depolarization -induced suppression of inhibition”.
These terms describe the phenomenon that a depolarization of the postsynaptic neuron at synapses leads to a reduction in the release of neurotransmitters at the presynaptic terminal . In the case of DSE it is the excitatory transmitter glutamate , in the case of DSI it is the inhibitory transmitter GABA .
The mechanism of DSE or DSI is the following: The post-synaptic depolarization leads to an influx of calcium - ion by activation of voltage-activated calcium channels . This leads to a postsynaptic release of endocannabinoids . Retrograde activates these presynaptic endocannabinoid receptors (in the brain CB1), which leads to a reduction in the release of neurotransmitters, probably through the inhibition of presynaptic calcium channels.
DSI was first discovered in pyramidal cells in the hippocampus , DSE in Purkinje cells in the cerebellum . Today we know that neither DSI nor DSE are limited to these cell types in the brain.
literature
- Marco A. Diana, Alain Marty: Endocannabinoid-mediated short-term synaptic plasticity: depolarization-induced suppression of inhibition (DSI) and depolarization-induced suppression of excitation (DSE) . In: British Journal of Pharmacology , May 2004; 142 (1): 9-19. PMC 1574919 (free full text)
- Alex Straiker, Ken Mackie: Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones . In: British Journal of Pharmacology , December 2005; 569 (Pt 2): 501-517. PMC 1464237 (free full text)
- Sodikdjon A. Kodirov, Julia Jasiewicz, Parisa Amirmahani, Dimitrios Psyrakis, Kathrin Bonni, Michael Wehrmeister, Beat Lutz: Endogenous cannabinoids trigger the depolarization-induced suppression of excitation in the lateral amygdala , on cshlp.org
- Anatol C. Kreitzer, Wade G. Regehr: Cerebellar Depolarization-Induced Suppression of Inhibition Is Mediated by Endogenous Cannabinoids (PDF), Department of Neurobiology, Harvard Medical School, Boston / Massachusetts. In: The Journal of Neuroscience , 2001, Vol. 21 RC174
- Emmanuel S. Onaivi, Takayuki Sugiura, Vincenzo Di Marzo: Endocannabinoids: The Brain and Body's Marijuana and Beyond . Taylor & Francis, Boca Raton / Florida, p. 141 (on Google Books )
- Heinz Steiner, Kuei Y. Tseng: Handbook of Basal Ganglia Structure and Function . Academic Press, 2nd edition 2017, p. 205 (on Google Books )
- Elisabeth J. Van Bockstaele: Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders . Springer Verlag, New York City 2013, p. 14 (on Google Books )