Diphenylbutylpiperidines
As diphenylbutylpiperidines a group of is drugs referred to, the structurally the butyrophenones are close to and as a common basic feature an aliphatic have chain, at the last C - atom to two p-Fluorphenylreste located. At the other end of the chain there is a residue that distinguishes the substances from one another.
The diphenylbutylpiperidines, like the butyrophenones, are used in psychiatry for the treatment of schizophrenia (i.e. as neuroleptics ).
Examples
Today common representatives of the Diphenylbutylpiperidines are
effect
Fluspirilen and Pimozid are highly potent neuroleptics . Their effect is similar to that of the highly potent butyrophenones.
unwanted effects
The side effects of diphenylbutylpiperidines also correspond to those of the stronger butyrophenones. Overall, the disruptive effects seem to be a little less pronounced than with the most potent butyrophenones, which, however , can be explained by the somewhat lower neuroleptic potency .
Historical
The two diphenylbutylpiperidines that are still in use today were explicitly developed with the aim of maximizing the security of intake.
This is also indicated by the trade names of the substances:
- IMAP ( fluspirilene ) means " in - A NTI P sychotikum"
- ORAP ( pimozide ) means " oral A NTI P sychotikum".
The injectable IMAP is intended to be administered once a week, while the ORAP is intended to be taken as a single daily dose (that was a step forward at the time).
The hopes placed in the diphenylbutylpiperidines with regard to a significant relief of neuroleptic therapy have hardly been fulfilled.
