Flus pirils

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Structural formula
Structure of flus pirils
General
Non-proprietary name Flus pirils
other names

8- [4,4-bis (4-fluorophenyl) butyl] -1-phenyl-1,3,8-triazaspiro [4.5] decan-4-one ( IUPAC )

Molecular formula C 29 H 31 F 2 N 3 O
External identifiers / databases
CAS number 1841-19-6
EC number 217-418-6
ECHA InfoCard 100.015.835
PubChem 3396
DrugBank DB04842
Wikidata Q408300
Drug information
ATC code

N05 AG01

Drug class

Neuroleptic

properties
Molar mass 475.57 g · mol -1
Physical state

firmly

Melting point

188-190 ° C

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
Toxicological data

106 mg kg −1 ( LD 50 ,  mouse ,  im )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Fluspirilen is a drug that is used to treat schizophrenia . It is a highly effective neuroleptic from the group of diphenylbutylpiperidines .

The prescription medication is in Germany under the brand name Imap ® (an abbreviation for I ntra m uskuläres A NTI P sychotikum) and Fluspi ® and fluspirilene beta ® marketed. If the relevant indication is present (acute productive and chronic schizophrenic psychoses (long-term therapy and relapse prevention)), i. m. be injected.

In a study from 1997, fluspiril was shown to be the second most common cause of tardive dyskinesia after haloperidol . Just a few applications can be enough to trigger dyskinesias. This is another reason why it is warned against its use in the treatment of depression .

See also

Individual evidence

  1. ↑ a b c Data sheet Fluspirilene from Sigma-Aldrich , accessed on April 2, 2011 ( PDF ).
  2. ↑ Arzneitelegram 06/1997 .
  3. ↑ Arzneitelegram 06/1997 .