Edgar Wingender

Edgar Wingender (born September 30, 1952 in Liebenau ) is a German biochemist , molecular biologist and bioinformatician . From 2002-2018 he was professor and director of the newly established department, later institute, for bioinformatics at the University Medical Center Göttingen (UMG).

Live and act

Edgar Wingender studied chemistry at the Technical University of Braunschweig , where he received his doctorate in 1980 in the field of biochemistry on the structure of the nucleosome . In the subsequent postdoctoral period with Klaus Seifart at the Philipps University of Marburg , he worked on transcription factors of RNA polymerase III until 1986 .

This was followed by research on protein design at the Society for Biotechnological Research (GBF) mbH (today the Helmholtz Center for Infection Research ) in Braunschweig , where he initiated the bioinformatics project for gene regulation in 1993 and headed the bioinformatics work group until 2002. During this time u. a. the TRANSFAC database , which he had previously founded on a private initiative, was the subject and later an important basis for a number of publicly funded projects.

Since 2002 Wingender was Professor of Bioinformatics at the Georg-August-Universität Göttingen and until retirement in 2018 Director of the Institute for Bioinformatics of the University Medical Center Göttingen (UMG).

In 1997 Wingender founded BIOBASE GmbH to sell and maintain the TRANSFAC database. From 2001 to 2010 he managed the company as one of two managing directors (President & CSO). In 2010 he founded the company geneXplain GmbH together with Alexander Kel in Wolfenbüttel , which he heads as CEO.

research

Today, Winger's research focus is on bioinformatics and systems biology research into gene regulatory networks .

Publications (selection)

Books

E. Wingender (ed.): Biological Petri Nets . Bioinformation Systems / IOS Press, Amsterdam 2010.
E. Wingender: Gene Regulation in Eukaryotes . VCH, Weinheim / New York / Basel / Cambridge 1993.

Technical article

E. Wingender, T. Schoeps, M. Haubrock, M. Krull, J. Dönitz: TFClass: expanding the classification of human transcription factors to their mammalian orthologs In: Nucleic Acids Res. 46, 2018, pp. D343-D347.
M. Haubrock, F. Hartmann, E. Wingender: NF-Y binding site architecture defines a c-Fos targeted promoter class In: PLoS ONE 11, 2016, S. e0160803.
X. Hua, L. Chen, J. Wang, J. Li, E. Wingender: Identifying cell-specific microRNA transcriptional start sites In: Bioinformatics 32, 2016, pp. 2403-2410.
E. Wingender, T. Schoeps, M. Haubrock, J. Dönitz: TFClass: a classification of human transcription factors and their rodent orthologs In: Nucleic Acids Res. 43, 2015, pp. D97-D102.
J. Dönitz, E. Wingender: EndoNet: An information resource about the intercellular signaling network In: BMC Syst. Biol. 8, 2014, p. 49.
E. Wingender: Criteria for an updated classification of human transcription factor DNA-binding domains In: J. Bioinform. Comput. Biol. 11, 2013, p. 1340007.
E. Wingender, T. Schoeps, T., J. Dönitz: TFClass: An expandable hierarchical classification of human transcription factors In: Nucleic Acids Res. 41, 2013, pp. D165-D170.
J. Li, X. Hua, M. Haubrock, J. Wang, E. Wingender: The architecture of the gene regulatory networks of different tissues In: Bioinformatics 28, 2012, pp. I509-514.
P. Stegmaier, M. Krull, N. Voss, A. Kel, E. Wingender: Molecular mechanistic associations of human diseases . In: BMC Syst. Biol. , 4, 2010, p. 1024.
E. Wingender: The TRANSFAC project as an example of framework technology that supports the analysis of genomic regulation . In: letter. Bioinform. , 9, 2008, pp. 326-332.
AP Potapov, B. Goemann, E. Wingender: The pairwise disconnectivity index as a new metric for the topological analysis of regulatory networks . In: BMC Bioinformatics , 9, 2008, p. 227.
A. Kel, N. Voss, T. Valeev, P. Stegmaier, O. Kel-Margoulis, E. Wingender: ExPlain: finding upstream drug targets in disease gene regulatory networks . In: SAR QSAR Environ Res . , 19, 2008, pp. 481-494.
A. Potapov, I. Liebich, J. Dönitz, K. Schwarzer, N. Sasse, T. Schoeps, T. Crass, E. Wingender: EndoNet: An information resource about endocrine networks . In: Nucleic Acids Res . , 34, 2006, pp. D540-D545.
M. Krull, S. Pistor, N. Voss, A. Kel, I. Reuter, D. Kronenberg, H. Michael, K. Schwarzer, A. Potapov, C. Choi, O. Kel-Margoulis, E. Wingender: TRANSPATH ^® : an information resource for storing and visualizing signaling pathways and their pathological aberrations . In: Nucleic Acids Res. , 34, 2006, pp. D546-D551.
T. Sauer, E. Shelest, E. Wingender: Evaluating phylogenetic footprinting for human-rodent comparisons . In: Bioinformatics , 22, 2006, pp. 430-437.
AE Kel, E. Gößling, I. Reuter, E. Cheremushkin, OV Kel-Margoulis, E. Wingender: MATCH ^™ : a tool for searching transcription factor binding sites in DNA sequences . In: Nucleic Acids Res. , 31, 2003, pp. 3576-3579.
YOU. Kloos, C. Choi, E. Wingender: The TGF-β-Smad network: introducing bioinformatic tools . In: Trends Genet. , 18, 2002, pp. 96-103, PMID 11818142 .
E. Wingender: Compilation of transcription regulating proteins . In: Nucleic Acids Res. , 16, 1988, pp. 1879-1902, PMC 338188 (free full text).

Web links

personal data
SURNAME	Wingender, Edgar
BRIEF DESCRIPTION	German biochemist, molecular biologist and bioinformatician
DATE OF BIRTH	September 30, 1952
PLACE OF BIRTH	Liebenau