Endothelin converting enzyme
| Endothelin converting enzyme 1 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 770 amino acids | |
| Secondary to quaternary structure | Homodimer, single pass type 2 membrane protein | |
| Cofactor | zinc | |
| Isoforms | A, B, C, D | |
| Identifier | ||
| Gene name | ECE1 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.4.24.71 , metallopeptidase | |
| MEROPS | M13.002 | |
| Response type | Hydrolysis of a Trp-Val bond | |
| Substrate | Prepro-endothelin | |
| Products | Endothelin 1 | |
| Occurrence | ||
| Homology family | Neprilysin family | |
| Parent taxon | Euteleostomi | |
The endothelin converting enzyme (ECE) is in many tissues of mammals spread (including humans) occurring enzyme . Endothelins are formed from their biologically inactive precursors, the prepro-endothelins, through proteolytic conversion. The rate-determining step of endothelin formation - the enzymatic hydrolysis of the intermediate big endothelin to endothelin - is catalyzed by the endothelin converting enzyme (endothelin conversion enzyme).
The endothelin-converting enzyme is a type II protease belonging to the neprilysin family of zinc metallopeptidases. There are various isoforms of the endothelin converting enzyme . The importance of the endothelin converting enzyme in the carcinogenesis of various types of cancer (especially in gynecological oncology and breast cancer ) and in the pathophysiology of Alzheimer's disease is currently being discussed.
Individual evidence
- ↑ N. Yanagisawa, H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto, T. Masaki: A novel vasoconstrictive peptide produced by vascular endothelial cells. In: Nature . 322, 1988, pp. 411-415.
- ↑ D. Xu, N. Emoto, A. Giaid, C. Slaughter, S. Kaw, D. de Wit, N. Yanagisawa: ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of endothelin-1. In: Cell . 78, 1994, pp. 473-485.
- ↑ M. Smollich: Significance of the endothelin system in gynecological oncology . GRIN, 2007, ISBN 978-3-638-67418-8 .
- ↑ M. Smollich, M. Götte, C. Kersting, J. Fischgränke, I. Radke, L. Kiesel, P. Wülfing: On the role of Endothelin-Converting Enzyme-1 (ECE-1) and neprilysin in human breast cancer . In: Breast Cancer Res Treat . 106, 2007, pp. 361-369.
- ↑ B. Funalot, T. Ouimet, A. Claperon, C. Fallet, A. Delacourte, J. Epelbaum, T. Subkowski, N. Léonard, V. Codron, JP David, P. Amouyel, JC Schwartz, N. Helbecque : Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease. In: Mol Psychiatry. 9 (12), 2004, pp. 1122-1128.