Ependymine
| Ependymine ( Danio rerio ) | ||
|---|---|---|
| Mass / length primary structure | 197 amino acids | |
| Secondary to quaternary structure | Homodimer | |
| Cofactor | Ca 2+ | |
| Identifier | ||
| Gene name (s) | epd (ZFIN) | |
| External IDs | ||
| Occurrence | ||
| Homology family | Ependymine | |
| Parent taxon | Clupeocephala | |
Ependymine is a glycoprotein isolated from the ependyma and extracellular fluid in the brain of bony fish . It is an adhesion molecule . Similar molecules called ependymin related proteins (ERP) have been found in amphibians, mammals and humans .
Ependymine occurs in two glycosylation variants: a 31 kDa mono-N-glycosylated form and a 37 kDa bi-N-glycosylated form. In the cerebrospinal fluid and the extracellular matrix of the goldfish, ependymine occurs with 15% protein and can be detected as mono-, di- and polymer, with the monomers being stabilized by calcium ions and the dimers by zinc ions. Although ependymines are produced in the fibroblasts of the meninx , they are also found on neurons.
The biological functions of the ependymines are still largely unknown. They could be involved in memory consolidation, as it has been shown that they have increased turnover after vestibulomotor conditioning of goldfish. Ependymine do not seem to be involved in learning, short-term memory, or memory performance of the goldfish, only in the consolidation of long-term memory.
Individual evidence
- ↑ J. Apostolopoulos et al .: Identification and characterization of a novel family of mammalian ependymin-related proteins (MERPs) in hematopoietic, nonhematopoietic, and malignant tissues. In: DNA Cell Biol. (10), 2001, pp. 625-635. PMID 11749721
- ↑ VE Shashoua: ependymin, a brain extracellular glycoprotein, and CNS plasticity. ( Memento of the original of February 14, 2006 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. In: Ann NY Acad Sci. 627, 1991, pp. 94-114.
