Fcγ receptor Ia

Fcγ receptor Ia
other names	CD64a, Fc-gamma RI, FcRI, High affinity immunoglobulin gamma Fc receptor I
	Existing structure data : PDB 3RJD , PDB 4W4O , PDB 4X4M
Properties of human protein
Mass / length primary structure	374 amino acids , 42,632 Da
Identifier
External IDs	GeneCards : FCGR1A ; UniProt : P12314 ;

The Fcγ receptor Ia (synonym CD64a ) is a surface protein from the group of Fcγ receptors .

properties

The Fcγ receptor Ia is formed by monocytes and macrophages (both phagocytes ). It binds the Fc region of immunoglobulin G (IgG) with high affinity . The affinity is higher than that of the Fcγ receptor Ib . The Fc.gamma receptor Ia is at the phagocytosis and antigen presentation via MHC I participated. It is glycosylated and phosphorylated .

The Fcγ receptor Ia binds to FCAR (synonym CD89 ) and the Fc region of immunoglobulin G. After binding of IgG, activation is initiated via the ITAM motif of the Fcγ receptor Ia located inside the cell .

Web links

MeSH Fcγ receptor Ia

Individual evidence

^ J. Lu, PD Sun: Structural mechanism of high affinity FcγRI recognition of immunoglobulin G. In: Immunological reviews. Volume 268, Number 1, November 2015, pp. 192-200, doi : 10.1111 / imr.12346 , PMID 26497521 .
↑ QM Hanson, AW Barb: A perspective on the structure and receptor binding properties of immunoglobulin G Fc. In: Biochemistry. Volume 54, number 19, May 2015, pp. 2931-2942, doi : 10.1021 / acs.biochem.5b00299 , PMID 25926001 , PMC 4894528 (free full text).
↑ Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG: Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89 / FcR gamma chain association . In: The Journal of Biological Chemistry . 270, No. 50, Dec 1995, pp. 29781-7. doi : 10.1074 / jbc.270.50.29781 . PMID 8530370 .
↑ M. Guilliams, P. Bruhns, Y. Saeys, H. Hammad, BN Lambrecht: The function of Fcγ receptors in dendritic cells and macrophages. In: Nature Reviews Immunology . Volume 14, Number 2, February 2014, pp. 94-108, doi : 10.1038 / nri3582 , PMID 24445665 .

[1] J. Lu, PD Sun: Structural mechanism of high affinity FcγRI recognition of immunoglobulin G. In: Immunological reviews. Volume 268, Number 1, November 2015, pp. 192-200, doi : 10.1111 / imr.12346 , PMID 26497521 .

[2] QM Hanson, AW Barb: A perspective on the structure and receptor binding properties of immunoglobulin G Fc. In: Biochemistry. Volume 54, number 19, May 2015, pp. 2931-2942, doi : 10.1021 / acs.biochem.5b00299 , PMID 25926001 , PMC 4894528 (free full text).

[pmid8530370-3] Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG: Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89 / FcR gamma chain association . In: The Journal of Biological Chemistry . 270, No. 50, Dec 1995, pp. 29781-7. doi : 10.1074 / jbc.270.50.29781 . PMID 8530370 .

[4] M. Guilliams, P. Bruhns, Y. Saeys, H. Hammad, BN Lambrecht: The function of Fcγ receptors in dendritic cells and macrophages. In: Nature Reviews Immunology . Volume 14, Number 2, February 2014, pp. 94-108, doi : 10.1038 / nri3582 , PMID 24445665 .