Functional proteomics

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Example protein profile

Functional proteomics (also biodynamic protein profile, flocculation profile, serum instability test , French bilan protéomique ) is an alternative medical blood test that aims to identify and remedy diseases. A profile of 44 precipitation reactions (flocculation) in the blood serum is determined for this purpose. The different reaction profiles should allow conclusions to be drawn about the state of internal organs. The effect of alternative medical remedies should also be made visible through changes in the profile.

Reagents and instructions are distributed by the private Center Europeen d'Informatique et d'Automation (CEIA) in Lacenas near Lyon . According to data from CEIA, there are around 1500 medical users across Europe. Scientific studies have not yet been submitted.

history

Functional proteomics was developed in the 1970s by the French doctors André Martin and Eric Reymond , the French biologist Jean Pacquelet and the Belgian doctor Pol Henry (1918-88, also the inventor of gemmotherapy ) from the serum lability test (protein precipitation, e.g. with zinc sulfate , ca.1910).

Basics

The flocculation leads to a change in the optical density of the serum, which is recorded densitometrically . The reaction kinetics have a typical course. The density measurement always takes place at the same point in time, namely at the point at which the reaction speed is at its maximum. The measurement results are given as a multiple of the standard deviation of a mean value from previous measurements available at CEIA. This should be based on a comparison group of patients of the same age and sex (however, there are no verified publications on this).

Applications

Protein groups according to molar mass and pH value
Protein groups according to diagnoses

Users of this method divide the colloidally dissolved proteins in the blood into coarse groups according to their mass and their chemical behavior, to which they ascribe certain clinical meanings. The specific assignment is very vague, e.g. For example, glycoproteins are supposed to indicate diseases with inflammatory reactions, metabolic derailments with pH shifts and neoplasms. The changes are treated with unspecified alternative medical drugs.

Areas of application

According to users, functional proteomics should be particularly suitable for the prevention and therapy of chronic and functional diseases: allergies, food intolerance, chronic inflammation, chronic pain, skin diseases, rheumatism, arthritis, osteoarthritis, vegetative disorders, chronic exhaustion and hormonal disorders.

literature

  • Eric Reymond: La Méthode du CEIA ou l'Analyse du Vivant, Brussels 1999 (éditions Satas, ISBN 2-87293-048-5 )
  • De Natura Rerum, International Medical Review for Documentation and Information: Les Bulletins d'Information Scientifique du CEIA, n ° 5, CEIA, 1982. Karl F. Haug Verlag, 1987-1995
  • F. Lasne: Floculation Test and Contemporary Biology, in: De Natura Rerum, International Medical Review for Documentation and Information, Karl F. Haug Verlag, 4, 1988
  • Sabine Fischer (Ed.): Functional Proteomics, Munich 2007 (Elsevier, ISBN 978-3-437-57920-2 )
  • Helmut Sauer: The CEIA flocculation profile in diagnostics and differential diagnostics of allergic diseases, In: EHK 2003/52; Pp. 241-256