Glucose-dependent insulinotropic peptide

from Wikipedia, the free encyclopedia
Glucose-dependent insulinotropic peptide
Glucose-dependent insulinotropic peptide
according to PDB  2OBU

Existing structural data: 1t5q, 2obu, 2b4n

Properties of human protein
Mass / length primary structure 42 aa; 4.98 kDa
Precursor (132 aa; 14.9 kDa)
Gene name GIP
External IDs
Parent taxon Higher mammals
human mouse
Entrez 2695 14607
Ensemble ENSG00000159224 ENSMUSG00000014351
UniProt P09681 Q9D887
Refseq (mRNA) NM_004123 NM_008119
Refseq (protein) NP_004114 NP_032145
Gene locus Chr 17: 44.39 - 44.4 Mb Chr 11: 95.89 - 95.89 Mb
PubMed search 2695 14607

The glucose-dependent insulinotropic peptide ( GIP ), formerly of the same acronym as Gastroinhibitorisches peptide or Gastrointestinal inhibitory peptide designated, consists of 42 amino acids and is in the K-cells of the duodenum ( the duodenum ) formed peptide hormone .

In the past, the neutralization of gastric acid (see pH value ) and the slowing down of gastric emptying were seen as the main effects. These effects are only observed at unphysiologically high GIP concentrations, but they are usually controlled by another hormone, namely secretin .

Today, a stimulation is the main effect of insulin in B-cells of the pancreas ( pancreatic shown) for food intake. Inhibiting the effect of GIP reduces the development of obesity and insulin resistance on a high-fat diet. It is believed that GIP plays a crucial role in the switch from fat oxidation to fat storage when the insulin effect declines. It could play an important role in the secondary prevention of insulin resistance.