Grammistine
| Grammist Gs F ( Grammistes sexlineatus ) | ||
|---|---|---|
| Mass / length primary structure | 25 amino acids | |
| Secondary to quaternary structure | Aggregate | |
| Identifier | ||
| External IDs | ||
| Occurrence | ||
| Parent taxon | Soap bass | |
Grammistines are members of a family of proteins previously only found in soap bass . They are short oligopeptides with 13 to 28 amino acids that probably aggregate to form a homooligomer. The fish secrete the mixture of six or seven grammistines on the skin. The individual proteins have different effects; However, all of them have an antibacterial effect against both gram-negative and gram- positive germs, and some are also hemolytic or poisonous to fish . So far, amino acid sequences of the grammistine of six-striped sea bass ( Grammistes sexilineatus ) and snowflake sea bass ( Pogonoperca punctata ) are known.
The LD50 of Grammistin Gs F in dental pups is 1.9 µg / ml.
further reading
- Sugiyama N, Araki M, Ishida M, Nagashima Y, Shiomi K: Further isolation and characterization of grammistins from the skin secretion of the soapfish Grammistes sexlineatus . In: Toxicon . 45, No. 5, April 2005, pp. 595-601. doi : 10.1016 / j.toxicon.2004.12.021 . PMID 15777955 .
- Shiomi K, Igarashi T, Yokota H, Nagashima Y, Ishida M: Isolation and structures of grammistins, peptide toxins from the skin secretion of the soapfish Grammistes sexlineatus . In: Toxicon . 38, No. 1, January 2000, pp. 91-103. doi : 10.1016 / S0041-0101 (99) 00136-1 . PMID 10669014 .
- Yokota H, Nagashima Y, Shiomi K: Interaction of grammistins with lipids and their antibacterial activity . In: Fisheries Science . 67, No. 5, 2002, pp. 928-993. doi : 10.1046 / j.1444-2906.2001.00343.x .