Hemosiderin
The hemosiderin (from Greek αίμα "blood" [see häm ] and σίδηρος "iron") consists of fragments of ferritin , the most important storage protein for iron . Chemically, it is a water-insoluble complex of iron and various proteins ; the iron content is about 37%. Unlike ferritin, hemosiderin is not a physiological storage form and can only be found intracellularly , especially in macrophages . It has a native golden yellow color; in histological sections it can be stained with the Prussian blue reaction and made visible.
Hemosiderin is particularly abundant in areas of major bleeding . Haemosiderin-laden macrophages (so-called " heart defect cells ", siderophages ) in the sputum can indicate heart failure . Diseases with increased iron deposition in the organism are called hemosideroses .
About history
The name Hämosiderin was coined in 1888 by Ernst Neumann (1834-1918), pathologist and hematologist from Königsberg . The so-called "law of exclusion of hemoglobin derivatives" also comes from him. In it Neumann claims that the blood pigment "hemosiderin" is formed in the living organism, while the "hematoidin" represents a pigment symbol of necrosis .
Individual evidence
- ↑ Premysl Põnka, Robert T. Woodworth, Herbert M. Schulman: Iron transport and storage . CRC Press, Boca Raton 1990, ISBN 0-8493-6677-1 , pp. 97 .
- ^ E. Neumann: Contributions to the knowledge of the pathological pigments , Virchows Archiv , Vol. 111 (1888). Pp. 394-399.