Hannah Monyer

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Hannah Monyer (born October 3, 1957 in Laslea , Romania ) is a Transylvanian-Saxon doctor and medical director at the University of Heidelberg . In 2004 she received the Gottfried Wilhelm Leibniz Prize .

Life

After attending a primary school and music school (originally she wanted to be a pianist) and an English boarding school in Romania, she emigrated from Romania in 1975 and went to Heidelberg, where she passed her Abitur in Heidelberg in 1976 after attending school for a year. She then studied medicine at the University of Heidelberg . In 1982 she received her doctorate under Dietrich von Engelhardt (Phenomenon of jealousy in Marcel Proust and in the psychiatric literature of his time). In 1983, after her license to practice medicine , she became an assistant doctor, first in Mannheim in child and adolescent psychiatry, then in 1984 in Lübeck in neuropediatrics.

As a post-doctoral student , she worked from 1986 at Stanford University Medical Center with Barry Tharp and Dennis W. Choi in neurology and from 1989 to 1994 at the Center for Molecular Biology at Heidelberg University with Peter Seeburg . 1993 habilitation they are there and received her teaching license for Biochemistry . In 1994 she became Hermann and Lilly Schilling endowed professor and was able to set up her own research group.

Hannah Monyer has been medical director of clinical neurobiology at the Heidelberg University Hospital since 1999. She is also a member of the Senate of the German Center for Neurodegenerative Diseases (DZNE).

research

The focus is on the investigation of the molecular mechanisms for the creation and modulation of synchronous neural network activities. Numerous nerve cells start to work at the same time and trigger cognitive processes , among other things . The aim is to find new knowledge about the cells and molecules that play key roles in these processes. It is hoped that this will provide new insights into mental and neurological illnesses that show a decline in cognitive abilities.

Networks of inhibitory interneurons with GABA receptors play a special role in the synchronous activity of neural networks, which are relevant for cognitive abilities such as learning and memory . Monyer was able to show that in addition to chemical synapses, these are also electrically connected to one another via gap junctions and that this is important for the synchronous oscillation of the nerve circuits on which cognitive functions are based. She studies mice with genetically modified GABA interneurons (for example with regard to their gap junctions) and the effects that these changes have on the cell and network level and in the behavior of the mice. It turned out that there are many different types of GABA interneuron networks that one tries to differentiate with fluorescent markers. It was also found that networks of GABA interneurons are also newly formed after birth and in adults.

In the 1990s she was involved in the discovery of the different molecular compositions of NMDA receptors (which play a role in the synaptic plasticity of the brain) and their different distribution and function in the brain. With Seeburg she also investigated different forms of AMPA receptors , which are also important for synaptic plasticity.

Awards and memberships

Fonts

  • with M. Gessmann: Das geniale Gedächtnis, Knaus, 2015
  • with Venance, Rozov, Blatow, Bunashev, Feldmeyer: Connexin expression in electrically coupled postnatal rat brain neurons, Proc. Nat. Acad. USA Vol. 97, 2000, 10260-10265
  • with EC Fuchs, H. Doheny, H. Faulkner, A. Caputi, RD Traub, A. Bibbig, N. Kopell, MA Whittington: Genetically altered AMPA-type glutamate receptor kinetics in interneurons disrupt long-range synchrony of gamma oscillation. Proc. Natl. Acad. Sci. USA, Vol. 98, 2001, pp. 3571-3576
  • with SG Hormuzdi, I. Pais, FEN LeBeau, SK Towers, A. Rozov, EH Buhl, MA Whittington: Impaired Electrical Signaling Disrupts Gamma Frequency Oscillations in Connexin 36 Deficient Mice, Neuron, Volume 31, 2001, pp. 487-495
  • with Meyer, Katona, Blatow, Rozov: In vivo labeling of pavalbumin-positive interneurons and analysis of electrical coupling in identified neurons, J. Neuroscience, Volume 22, 2002, 7055-7064
  • with Isabel Pais, Sheriar G. Hormuzdi, Roger D. Traub, Ian C. Wood, Eberhard H. Buhl, Miles A. Whittington, Fiona EN LeBeau: Sharp Wave-Like Activity in the Hippocampus In Vitro in Mice Lacking the Gap Junction Protein Connexin 36, Journal of Neurophysiology, Vol. 89, 2003, pp. 2046-2054, online
  • mit Bruzzone, Hormuzdi, Barb, Herb: Pannexins, a family of gap junction proteins expressed in brain, Proc. Nat. Acad. USA, Vol. 100, 2003, 13644-13649
  • mit Blatow, Rozov, Katona, Hormuzdi, Meyer, Whittington, Caputi: A novel network of multipolar bursting interneurons generates theta oscillatons in neocortex, Neuron, Volume 38, 2003, 805-817
  • with G. Nase, Wolf Singer , AK Engel: Features of neural synchrony in mouse visual cortex, Journal of Neurophysiology, Volume 90, 2003, pp. 1115-1123
  • with H. Markram: Interneuron Diversity series: Molecular and genetic tools to study GABAergic interneuron diversity and function, Trends Neuroscience, Volume 27, 2004, 90-97
  • with Hormuzdi, Filippov, Mitropoulou, Bruzzone: Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks, Biochimia et Biophysica Acta, Volume 1662, 2004, 113-137
  • with David M. Bannerman, Rolf Sprengel, David J. Sanderson, Stephen B. McHugh, J. Nicholas P. Rawlins, Peter H. Seeburg: Hippocampal synaptic plasticity, spatial memory and anxiety, Nature Reviews Neuroscience, Volume 15, 2004, 181 -192
  • with Christie, Bark, Hormuzdi, Helbig, Westbrook: Connexin36 mediates spike synchrony in olfactory bulb glomeruli, Neuron, Volume 46, 2005, pp. 761-772
  • with M. Blatow, A. Caputi: Molecular diversity of neocortical GABAergic interneurones. Review. J. Physiology, Vol. 562, 2005, pp. 99-105
  • with Sarah Melzer, Magdalena Michael, Antonio Caputi, Marina Eliava, Elke Fuchs, Miles Whittington: Long-Range-Projecting GABAergic Neurons Modulate Inhibition in Hippocampus and Entorhinal Cortex, Science, Volume 335, 2012, 1506-1510, abstract
  • with A. Caputi, S. Melzer: The long and short of GABAergic neurons, Current Opinions Neurobiology, Volume 23, 2013, 179-186

Web links

Individual evidence

  1. ↑ Hannah Monyer, Rolf Sprengel, Ralf Schoepfer, Anne Herb, Miyoko Higuchi, Hilda Lomeli, Nail Burnashev, Bert Sakmann, Peter H. Seeburg: Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes, Science, Volume 256, 1992, p. 1217-1221, abstract
  2. ↑ Member entry by Prof. Dr. Hannah Monyer (with picture) at the German Academy of Sciences Leopoldina , accessed on July 19, 2016.
  3. ^ Members of the HAdW since it was founded in 1909. Hannah Monyer. Heidelberg Academy of Sciences, accessed on June 22, 2016 .
  4. ↑ EMBO enlarges its membership for 50th anniversary. Press release from May 8, 2014 at the Science Information Service (idw-online.de)
  5. ^ Membership directory: Hannah Monyer. Academia Europaea, accessed July 7, 2017 .
  6. ↑ Stefanie Seltmann: Taiwan's highest scientific award for Hannah Monyer. German Cancer Research Center, press release from March 16, 2017 from Informationsdienst Wissenschaft (idw-online.de), accessed on March 16, 2017.
personal data
SURNAME Monyer, Hannah
BRIEF DESCRIPTION Romanian physician and neurobiologist
DATE OF BIRTH October 3, 1957
PLACE OF BIRTH Grosslasseln , Romania