Hans Werner Müller (neurobiologist)

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Hans Werner Müller (* around 1950) is a German neurobiologist . He heads the Molecular Neurobiology group and is a professor at Heinrich Heine University in Düsseldorf (HHU).

Life

Müller studied biology and chemistry at Johannes Gutenberg University Mainz from 1969 with a diploma in biology in 1975 and the 1st state examination in chemistry in 1976. After that, he was in 1977/78 for a research stay at the Arrhenius Laboratory of Stockholm University and in 1978 he was at the University of Mainz, PhD in biology (dissertation on bioenergetics). As a post-doctoral student and research assistant, he then worked at the Friedrich Miescher Laboratory of the Max Planck Society in Tübingen and from 1982 to 1984 as a scholarship holder of the German Research Foundation (DFG) at Stanford Universityin the Department of Neurobiology. Since 1985 he has headed the molecular neurobiology research group at the HHU Neurological Clinic. In 1988 he completed his habilitation and became a professor in 1993.

Since 1991 he has been on the board of the Biological-Medical Research Center (BMFZ) of the HHU and was its deputy spokesman from 1999 to 2006.

From 1994 to 2001 he was the spokesman for the DFG research group Molecular Biology of Neurodegenerative Diseases and from 1998 to 2005 one of the coordinators of the DFG priority program Molecular Foundations of Neural Repair Mechanisms .

In 2001 he was the scientific founder and member of the supervisory board of Spinal Cord Therapeutics GmbH (formerly Neuraxo-Biotec) in Erkrath .

From 2003 to 2007 he was a member of the board of the Neuroscientific Society (NWG) and spokesman for its “Molecular Neurobiology” section. In 2009 he was the scientific founder and then deputy chairman of the CNR eV (Center for Neuronal Regeneration) in Düsseldorf.

plant

He researches the molecular mechanisms of the regeneration of the axons in the peripheral and central nervous system, for example after spinal cord injuries that lead to paralysis, and possible therapies (functional regeneration).

In contrast to the peripheral nervous system, damaged nerve lines in the central nervous system generally do not regenerate (see axon regeneration ). Scars with a collagen scaffold and nerve growth inhibitors are formed. One point of attack by Müller's group was therefore to use drugs to delay scar formation, for example in the case of injuries to the spinal cord, in order to enable regeneration. In 2007 they also discovered that stromal cell-derived factor-1 (SDF-1) can promote neurite outgrowth in vitro in the presence of inhibiting myelein. His group is also studying stem cells, the effects of polyethylene glycol and the implantation of micro-connectors. Müller examines the molecular basis of the regulation of nerve fiber regeneration (RAG genes - regeneration associated genes - and the proteins corresponding to them ) and the roles of glial cells and extracellular matrix in this context.

Fonts

  • as editor: Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems Biology. Wiley-VCH 2008.
  • with Veronica Estrada and Ayse Tekinay: Neural ECM mimetics. In: Alexander Dityaev, Bernhard Wehrle-Haller, Asla Pitkänen: Brain Extra-Cellular Matrix in Health and Disease. (= Progress in Brain Research. 214). Elsevier 2014, ISBN 978-0-444-63548-8 , chapter 16.
  • V. Estrada, N. Brazda, C. Schmitz, S. Heller, H. Blazyca, R. Martini, HW Müller: Long-lasting significant functional improvement in chronic severe spinal cord injury following scar resection and polyethylene glycol implantation. In: Neurobiol. Dis. Volume 67, 2014, pp. 165-179.
  • N. Brazda, C. Voss, V. Estrada, H. Lodin, N. Weinrich, K. Silk, J. Müller, HW Müller: A mechanical microconnector system for restoration of tissue continuity and long-term drug application into the injured spinal cord. In: Biomaterials. Volume 34, 2013, pp. 10056-10064.
  • J. Schira, M. Gasis, V. Estrada, M. Hendricks, C. Schmitz, T. Trapp, F. Kruse, G. Kögler, P. Wernet, HW Müller: Significant clinical, neuropathological and behavioral recovery from acute spinal cord trauma by transplantation of a well-defined somatic stem cell from human umbilical cord blood. In: Brain. Volume 135, 2012, pp. 431-446.
  • J. Opatz, P. Küry, N. Schiwy, A. Järve, V. Estrada, N. Brazda, F. Bosse, HW Müller: SDF-1 stimulates neurite growth on inhibitory CNS myelin. In: Mol. Cell. Neurosci. Tape. 40, 2009, pp. 293-300.
  • N. Klapka, S. Hermanns, G. Straten, C. Masanneck, S. Duis, F. Hamers, D. Müller, W. Zusratter, HW Müller: Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery. In: Eur. J. Neurosci. Volume 22, 2005, pp. 3047-3058.
  • P. Küry, R. Greiner-Petter, C. Cornely, T. Jürgens, HW Müller: Mash 2 is expressed in the adult sciatic nerve and regulates the expression of Krox24, Mob-1, CXCR4 and p57kip2 in Schwann cells. In: J. Neurosci. Volume 22, 2002, pp. 7586-7595.
  • G. Zoidl, S. Blass-Kampmann, D. D'Urso, C. Schmalenbach, HW Müller: Retroviral-mediated gene transfer of the peripheral myelin protein PMP22 in Schwann cells: modulation of cell growth. In: EMBO J. Volume 14, 1995, pp. 1122-1128.
  • N. Matsunami, B. Smith, L. Ballard, MW Lensch, M. Robertson, H. Albertsen, CO Hanemann, HW Müller, T. Bird, R. White, PF Chance: Peripheral myelin protein-22 gene maps in the duplication in chromosome 17p11.2 associated with Charcot-Marie-Tooth 1A. In: Nature Genetics. Volume 1, 1992, pp. 176-179.
  • P. Spreyer, G. Kuhn, CO Hanemann, C. Gillen, H. Schaal, R. Kuhn, G. Lemke, HW Müller: Axon-regulated expression of a Schwann cell transcript that is homologous to a "growth arrest-specific" gene. In: EMBO J. Vol. 10, No. 12, December 1991, pp. 3661-3668.
  • HW Müller, PJ Gebicke-Härter, DH Hangen, EM Shooter: A specific 37,000-Dalton protein that accumulates in regenerating but not in nonregenerating mammalian nerves. In: Science. Volume 228, 1985, pp. 499-501.

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personal data
SURNAME Müller, Hans Werner
BRIEF DESCRIPTION German neurobiologist
DATE OF BIRTH around 1950