Hitoshi Nozaki

Hitoshi Nozaki (born 1922 in Okayama ; † September 25, 2019 ) was a Japanese chemist ( organic chemistry ). He became known for the Nozaki-Hiyama-Kishi reaction , a metal-catalyzed coupling reaction that became important for modern organometallic chemistry. It is also named after Tamejiro Hiyama and Yoshito Kishi .

biography

Nozaki studied from 1943 at the University of Kyoto , where he also received his doctorate and became a professor (full professorship from 1963). In 1985 he retired in Kyoto and was then (until 1996) professor at Okayama University.

His students included the Nobel Prize winner Ryoji Noyori , Yoshito Kishi and Tamejiro Hiyama (from 1972 his assistant).

plant

He dealt with organic synthesis and was considered the doyen of organic chemistry in Japan. Among other things, he dealt with the synthesis of terpenes .

He developed the Nozaki-Hiyama-Kishi reaction for the synthesis of aldehydes with Hiyama in 1977. It was in a way the chromium analogue of the magnesium-based Grignard reaction , but in contrast to this it reacted very selectively with aldehydes and, in contrast to the, tolerated Grignard reaction has a number of functional groups, which makes it more widely applicable. Reproducibility problems have been attributed to the need for a small amount of nickel to be added by Nozaki and Hiyama in conjunction with the Yoshito Kishi group .

Honors and memberships

In 1979 he received the Chemistry Society of Japan Prize, the Japan Academy Prize in 1986, the Purple Ribbon Medal in 1986, the Order of the Sacred Treasure in 1992, and in 1999 he became a member of the Japan Academy. In 1993 he received the Japanese Society's Special Prize for Synthetic Organic Chemistry. 1985/86 he was President of the Japanese Society for Synthetic Organic Chemistry.

Fonts (selection)

Except for the works cited in the footnotes.

with T. Hiyama, K. Takai, K. Kimura, T. Kuroda: Selective grignard-type carbonyl addition of alkenyl halides mediated by chromium (II) chloride , Tetrahedron Letters, Volume 24, 1983, pp. 5281-5284

Web links

Japanese biography , Chem-Station 2009

Individual evidence

↑ 野崎一会員の逝去について. Retrieved October 4, 2019 (Japanese).
↑ Y. Okude, S. Hirano, T. Hiyama, H. Nozaki: Grignard-type carbonyl addition of allyl halides by means of chromous salt. A chemospecific synthesis of homoallyl alcohols , J. Am. Chem. Soc., Vol. 99, 1977, pp. 3179-3181.

personal data
SURNAME	Nozaki, Hitoshi
BRIEF DESCRIPTION	Japanese chemist
DATE OF BIRTH	1922
PLACE OF BIRTH	Okayama
DATE OF DEATH	September 25, 2019

[1] 野崎一会員の逝去について. Retrieved October 4, 2019 (Japanese).

[2] Y. Okude, S. Hirano, T. Hiyama, H. Nozaki: Grignard-type carbonyl addition of allyl halides by means of chromous salt. A chemospecific synthesis of homoallyl alcohols , J. Am. Chem. Soc., Vol. 99, 1977, pp. 3179-3181.