Hypoalbuminemia is caused by reduced albumin formation due to chronic liver damage, malnutrition or albumin loss, which can occur in acute inflammations and burns or via the kidneys in the event of kidney damage.
Physiological hypoalbuminemia is seen in pregnancy, where it appears - usually in the third trimester - as a consequence of proteinuria with predominantly albuminuria and is responsible for the deposits ( edema ) in the pregnant woman. The cause is on the one hand the increased plasma volume and on the other hand the increased glomerular patency, which leads to the renal excretion of albumin. However, a moderately increased loss of albumin in the urine (> 300 mg protein / 24 h) can no longer be classified as harmless and can indicate the onset of preeclampsia ; a loss of> 3 g protein / 24 h is considered severe.
Symptoms and consequences
Due to the lack of albumin, the colloid-osmotic pressure in the blood plasma drops , water cannot be held in physiological quantities in the vascular system and passes into the interstitium , which can lead to edema or pleural effusion .
Since albumin is the most common protein in the human body and is responsible, among other things, for the transport of endogenous (e.g. hormones) and exogenous (e.g. drugs) substances, their concentration in the blood and thus their effectiveness is reduced by one Albumin deficiency influences.
- Alphabetical directory for the ICD-10-WHO version 2019, volume 3. German Institute for Medical Documentation and Information (DIMDI), Cologne, 2019, p. 393
- Albumin in the serum on the website of the Institute for Clinical Chemistry of the University Hospital Ulm ( Memento of the original from April 14, 2016 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.
- Proteinuria on proteineeiweiss.de
- Article "Pregnancy - Changes" in the portal of women
- Berthold Jany, Tobias Welte: Pleural effusion in adults - causes, diagnosis and therapy. In: Deutsches Ärzteblatt. Volume 116, Issue 21, (May) 2019, pp. 377–385, here: pp. 379–382.