Idarubicin

Structural formula
General
Surname	Idarubicin
other names	(7 S - cis ) -9-acetyl-7 - [(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl) oxy] -7,8,9,10-tetrahydro-6, 9,11-trihydroxy-5,12-naphthacenedione 4-demethoxide unorubicin
Molecular formula	C 26 H 27 NO 9
External identifiers / databases
CAS number 58957-92-9 57852-57-0 ( hydrochloride ) PubChem 42890 ChemSpider 39117 DrugBank DB01177 Wikidata Q1063862
Drug information
ATC code	L01 DB06
properties
Molar mass	533.95 g mol −1
Physical state	firmly
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS labeling of hazardous substances Hydrochloride danger H and P phrases H: 300-351-360 P: 201-264-281-301 + 310-308 + 313
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Idarubicin , also 4-demethoxidaunorubicin, is a substance belonging to the anthracyclines .

use

It is used as a cytostatic agent as part of the combination chemotherapy for acute leukemia.

Idarubicin is a DNA - intercalator . The lack of a methoxy group compared to daunorubicin improves fat solubility and thus the uptake into the cell, where it then comes to growth-inhibiting interaction with topoisomerase II .

literature

• Franz v. Bruchhausen, Eberhard Hackenthal, Siegfried Ebel: Hagers Handbook of Pharmaceutical Practice . Springer DE, 1999, ISBN 3-540-62644-1 , pp. 667 ( limited preview in Google Book search).
• Margaret Barton Burke, Gail M. Wilkes, Karen Ingwersen: Cancer Chemotherapy Care Plans Handbook . Jones & Bartlett Learning, 2002, ISBN 0-7637-1481-X , pp. 306 ( limited preview in Google Book search).

Individual evidence

1. ↑ ^{a b c} Data sheet Idarubicin hydrochloride, solid from Sigma-Aldrich , accessed on January 31, 2013 ( PDF ).
2. ↑ Peter H. Wiernik: Adult Leukemias . PMPH-USA, 2001, ISBN 1-55009-111-5 , pp. 206 ( limited preview in Google Book search).