Ionotropic receptor
| Ionotropic receptor | ||
|---|---|---|
| Secondary to quaternary structure | Pentamer | |
| Transporter classification | ||
| TCDB | 1.A.9 | |
| designation | Ionotropic receptors | |
| Occurrence | ||
| Parent taxon | Prokaryotes , multicellular animals | |
Ionotropic receptors (or ion channel receptors ) consist of membrane-bound protein subunits that have extracellular binding domains for their respective ligands and form an ion channel .
In the case of ionotropic receptors , both the binding of the ligand and the first stage of signal transduction take place on a macromolecule . Due to the specific binding of the respective natural ligand or an agonist , the conductivity of the cell membrane changes when the channel is opened , which results in a change in the membrane potential .
Examples of ionotropic receptors:
- the acetylcholine receptor at the neuromuscular junction , the synapse between motor neurons and skeletal muscle fiber
- of the glutamate receptors in the central nervous system : the AMPA receptor , the kainate receptor and the NMDA receptor .
See also
literature
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- RW Olsen, W. Sieghart: International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update. In: Pharmacol. Rev. 60 (3), September 2008, pp. 243-260. doi: 10.1124 / pr.108.00505 . PMC 2847512 (free full text). PMID 18790874 .
- SB Hansen, X. Tao, R. MacKinnon: Structural basis of PIP2 activation of the classical inward rectifier K + channel Kir2.2. In: Nature. 477 (7365), September 2011, pp. 495-498. doi: 10.1038 / nature10370 . PMC 3324908 (free full text). PMID 21874019 .
- MD Krasowski, NL Harrison: General anaesthetic actions on ligand-gated ion channels. In: Cell. Mol. Life Sci. 55 (10), 1999, pp. 1278-1303. doi: 10.1007 / s000180050371 . PMC 2854026 (free full text). PMID 10487207 .
- JP Dilger: The effects of general anesthetics on ligand-gated ion channels. In: Br J Anaesth. 89 (1), 2002, pp. 41-51. doi: 10.1093 / bja / aef161 . PMID 12173240 .
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