Jeannie T. Lee

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Jeannie T. Lee is an American geneticist and professor of genetics and pathology at Harvard Medical School and Massachusetts General Hospital and a researcher at the Howard Hughes Medical Institute .

Life

Lee is known for her research into the inactivation of the X chromosome and the functions of a new class of epigenetic regulators known as long noncoding RNA (lncRNA). She received her BA in Biochemistry and Molecular Biology from Harvard College and an MD / PhD from the University of Pennsylvania School of Medicine. She did her PhD on Fragile X Syndrome , where she began to be interested in X inactivation and epigenetics and then worked as a postdoc with Rudolf Jaenisch at the Whitehead Institute . She is a member of the Genetics Society of America .

Lee entered faculty at Harvard in 1997, devoting himself to research on sex chromosome dynamics during development and disease. Her most important achievements include the identification of the X-inactivation center, the discovery of the Tsix-Antisense RNA, the determination of the Xist's mechanism and the proof that RNA is a regulator of the Polycomb-Repressive-Complex 2. After Lee was awarded the Lurie Prize, Dr. Charles A. Sanders of the Foundation for the National Institutes of Health said: "Dr. Lee's work has revolutionized the field of epigenetics. Your research has made groundbreaking contributions and we now better understand the unique role played by long non-coding RNAs play in gene expression, which could lead to the development of new therapeutics. "

Awards

Individual evidence

  1. ^ Jeannie T. Lee, MD, PhD | HHMI.org . In: HHMI.org . ( hhmi.org [accessed May 25, 2018]).
  2. ↑ J Viegas: QnAS with Jeannie T. Lee . In: Proc Natl Acad Sci USA . 112, September, pp. 14745-6. doi : 10.1073 / pnas.1521185112 . PMID 26582793 . PMC 4672782 (free full text).
  3. ^ National Academy of Sciences - http://www.nasonline.org : Jeannie Lee. Retrieved May 25, 2018 .
  4. ↑ JT Lee, WM Strauss, JA Dausman, R. Jaenisch: A 450 kb transgene displays properties of the mammalian X-inactivation center . In: Cell . 86, No. 1, July 12, 1996, ISSN  0092-8674 , pp. 83-94. PMID 8689690 .
  5. ↑ JT Lee, N. Lu, Y. Han: Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain . In: Proceedings of the National Academy of Sciences . 96, No. 7, March 30, 1999, ISSN  0027-8424 , pp. 3836-3841. PMID 10097124 .
  6. ↑ JT Lee, LS Davidow, D. Warshawsky: Tsix, a gene antisense to Xist at the X-inactivation center . In: Nature Genetics . 21, No. 4, April 1999, ISSN  1061-4036 , pp. 400-404. doi : 10.1038 / 7734 . PMID 10192391 .
  7. ↑ Jing Zhao, Bryan K. Sun, Jennifer A. Erwin, Ji-Joon Song, Jeannie T. Lee: Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome . In: Science . 322, No. 5902, October 31, 2008, ISSN  1095-9203 , pp. 750-756. doi : 10.1126 / science.1163045 . PMID 18974356 . PMC 2748911 (free full text).
  8. ↑ Anand Minajigi, John Froberg, Chunyao Wei, Hongjae Sunwoo, Barry Kesner, David Colognori, Derek Lessing, Bernhard Payer, Myriam Boukhali: A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation . In: Science . 349, No. 6245, July 17, 2015, ISSN  0036-8075 . doi : 10.1126 / science.aab2276 . PMID 26089354 . PMC 4845908 (free full text).
  9. ↑ Jing Zhao, Bryan K. Sun, Jennifer A. Erwin, Ji-Joon Song, Jeannie T. Lee: Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome . In: Science . 322, No. 5902, October 31, 2008, ISSN  1095-9203 , pp. 750-756. doi : 10.1126 / science.1163045 . PMID 18974356 . PMC 2748911 (free full text).
  10. ↑ Jing Zhao, Toshiro K. Ohsumi, Johnny T. Kung, Yuya Ogawa, Daniel J. Grau, Kavitha Sarma, Ji Joon Song, Robert E. Kingston, Mark Borowsky: Genome-wide identification of polycomb-associated RNAs by RIP-seq . In: Molecular Cell . 40, No. 6, December 22, 2010, ISSN  1097-4164 , pp. 939-953. doi : 10.1016 / j.molcel.2010.12.011 . PMID 21172659 . PMC 3021903 (free full text).
  11. ↑ Catherine Cifuentes-Rojas, Alfredo J. Hernandez, Kavitha Sarma, Jeannie T. Lee: Regulatory interactions between RNA and polycomb repressive complex 2 . In: Molecular Cell . 55, No. 2, July 17, 2014, ISSN  1097-4164 , pp. 171-185. doi : 10.1016 / j.molcel.2014.05.009 . PMID 24882207 . PMC 4107928 (free full text).
  12. ↑ Athanasios Zovoilis, Catherine Cifuentes-Rojas, Hsueh-Ping Chu, Alfredo J. Hernandez, Jeannie T. Lee: Destabilization of B2 RNA by EZH2 Activates the Stress Response . In: Cell . 167, No. 7, December 15, 2016, ISSN  1097-4172 , pp. 1788-1802.e13. doi : 10.1016 / j.cell.2016.11.041 . PMID 27984727 . PMC 5552366 (free full text).
  13. ^ Foundation for the NIH to Award Lurie Prize in Biomedical Sciences to Dr. Jeannie Lee for Pioneering Work in Epigenetics | FNIH .
  14. ↑ http://www.oligotherapeutics.org/interview-with-jeannie-t-lee-md-phd/
  15. ^ Lee, Jeannie T. In: AAAS - The World's Largest General Scientific Society . February 9, 2018 ( aaas.org [accessed May 25, 2018]).
  16. ↑ http://www.nasonline.org/member-directory/members/20033180.html
  17. ↑ Centennial Awards honor outstanding GENETICS articles ( en ) Accessed September 30, 2017.
personal data
SURNAME Lee, Jeannie T.
BRIEF DESCRIPTION American geneticist and professor of genetics and pathology
DATE OF BIRTH 20th century