Johann Bauersachs

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Johann Bauersachs

Johann Bauersachs (born April 22, 1966 in Karlsruhe ) is a German internist, cardiologist , intensive care physician , university professor at the Hannover Medical School and there director of the Clinic for Cardiology and Angiology. He is known for his scientific contributions in the fields of acute coronary syndrome , left ventricular healing and remodeling after ischemia, and acute and chronic heart failure .

Life

After studying human medicine and obtaining his doctorate at the University of Freiburg in 1993, Bauersachs was a research assistant and assistant doctor at the Medical Clinic IV and at the Institute for Cardiovascular Physiology at the University Hospital in Frankfurt and at the Medical Clinic II, University Hospital Mannheim . In 2001, Professor Bauersachs completed his habilitation in internal medicine at the Würzburg University Hospital and received the Venia legendi . In 2008 he was appointed adjunct professor and senior physician at the Medical Clinic I at the Würzburg University Hospital. Bauersachs has been W3 professor and director of the Clinic for Cardiology and Angiology at the Hannover Medical School since 2010 .

Scientific contribution

The scientific work of Bauersachs initially concentrated on the endothelium-dependent dilation of blood vessels, which is decisive for the regulation of blood pressure and organ perfusion . Research work is carried out after experimental myocardial infarction in rats and mice. For the first time, there was evidence of a positive influence on left ventricular remodeling after myocardial infarction through treatment with statins. The research activities also extended to clinical studies to improve therapy with MR antagonists for heart attacks and cardiac and renal insufficiency.

Together with T. Thum, fundamental work was carried out on the role of non-coding RNA, in particular microRNA , in cardiovascular diseases, which also led to patents for the treatment of heart and vascular diseases. For the first time, the importance of microRNAs for fetal reprogramming of gene expression in heart failure was demonstrated and the first application of an antagomir for the treatment of heart failure was carried out in an animal model. Bauersachs is continuing this research activity in the REBIRTH Cluster of Excellence at the Hannover Medical School. The focus was on translation into clinical application. as well as the large endpoint study DIGIT-HF

In addition to his research activities, Bauersachs also made contributions to scientific research as a co-editor and reviewer for medical and scientific journals, as an organizer of congresses and as a committee member / reviewer for international institutions promoting science such as the German Research Foundation (since 2012 as a review board), INSERM (France), ANR (France), Wellcome Trust (UK), the German Heart Foundation , and the EU.

Memberships in scientific associations

Bauersachs is a Board Member of the Heart Failure Association (HFA) of the European Society for Cardiology and Chair of the HFA Study Group on Peripartum Cardiomyopathy. He is a member of the program committees of the German Society for Cardiology and the German Society for Internal Medicine . He is also the chairman of ESAC Germany, the association for the promotion of aldosterone research, and one of the coordinators of the EU-funded COST Action ADMIRE (Aldosterone and Mineralocorticoid Receptor). Bauersachs is a member of the editorial boards of Hypertension , Cardiovascular Research , Basic Research in Cardiology and Clinical Research in Cardiology . Bauersachs is an interventional cardiologist with special interests in acute coronary syndromes, left ventricular healing and remodeling processes, acute and chronic heart failure, and intensive care medicine. Bauersachs has been a review board member of the German Research Foundation since 2012 . Between 1999 and 2010 he was scientific secretary of the Collaborative Research Centers 355 and 688 at the University of Würzburg. In the REBIRTH (From Regenerative Biology to Reconstructive Therapy) cluster of excellence , he is a member of the Steering Committee and Area Manager. Since October 1st, 2016, Bauersachs has been the spokesman for the DFG-funded Clinical Research Group KFO311 "(Pre-) terminal heart and lung failure: mechanical relief and repair".

Awards

  • 2001 Oskar Lapp Prize from the German Society for Cardiology
  • 2004 Albert Fraenkel Prize of the German Society for Cardiology
  • 2006 Parmley Prize from the American College of Cardiology
  • 2012 Bernard and Joan Marshall Distinguished Investigator Award, British Society for Cardiovascular Research

Publications

Bauersachs published more than 300 scientific articles (as of December 2016).

Web links

Individual evidence

  1. ↑ J. Bauersachs, R. Popp, M. Hecker, E. Sauer, I. Fleming, R. Busse: Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. In: Circulation. 1996.
  2. ↑ J. Bauersachs, P. Galuppo, D. Fraccarollo, M. Christ, G. Ertl: Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme a reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction. In: Circulation. 2001.
  3. ↑ J. Bauer Sachs, F. Jaisser, R. Toto: mineralocorticoid receptor activation and mineralocorticoid receptor antagonist treatment in Cardiac and Renal Diseases. In: Hypertension. 65, 2015, pp. 257-263.
  4. ↑ T. Thum, P. Galuppo, C. Wolf, J. Fiedler, S. Kneitz, LW van Laake, PA Doevendans, CL Mummery, J. Borlak, A. Haverich, C. Gross, S. Engelhardt, G. Ertl , J. Bauersachs: MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure. In: Circulation. 116, 2007, pp. 258-267.
  5. ↑ T. Thum, P. Galuppo, C. Wolf, J. Fiedler, S. Kneitz, LW van Laake, PA Doevendans, CL Mummery, J. Borlak, A. Haverich, C. Gross, S. Engelhardt, G. Ertl , J. Bauersachs: MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure. In: Circulation. 116, 2007, pp. 258-267.
  6. ↑ T. Thum, C. Gross, T. Fischer, J. Fiedler, S. Just, W. Rottbauer, M. Bussen, P. Galuppo, S. Frantz, M. Castoldi, M. Muckenthaler, J. Soutschek, V Koteliansky, A. Rosenwald, J. Bauersachs *, S. Engelhardt *: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signaling in fibroblasts. In: Nature. 456, 2008, pp. 980-984. * joint senior authors
  7. ↑ REBIRTH "From Regenerative Biology to Reconstructive Therapy" (MHH) Cluster of Excellence at mh-hannover.de, accessed on August 19, 2019.
  8. ↑ A. Haghikia, E. Podewski, D. Berlin, K. Sunshine, D. Fischer, CE Angermann, M. Böhm, P. X, J. Bauer Sachs, D. Hilfiker-Kleiner: Rationale and design of a randomized, controlled multicentre clinical trial to evaluate the effect of bromocriptine on left ventricular function in women with peripartum cardiomyopathy. In: Clin Res Cardiol. May 1, 2015.
  9. ↑ U. Bavendiek, L. Aguirre Davila, A. Koch, J. Bauersachs: Assumption versus evidence - the case of digoxin in atrial fibrillation and heart failure. In: Eur Heart J. pii, Jan 2017, ehw577 2016.
  10. ↑ HFA ( Memento of the original from July 11, 2017 in the Internet Archive ) Info: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.  @1@ 2Template: Webachiv / IABot / www.escardio.org
  11. ↑ ESAC Germany
  12. ↑ Aldosterone and mineralocorticoid receptor (ADMIRE) ( Memento of the original from April 23, 2017 in the Internet Archive ) Info: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.admirecost.eu
  13. ↑ hypertension
  14. ^ Basic Research in Cardiology
  15. ↑ CRC
  16. ↑ KFO311
personal data
SURNAME Bauersachs, Johann
BRIEF DESCRIPTION German cardiologist
DATE OF BIRTH April 22, 1966
PLACE OF BIRTH Karlsruhe