KCNQ4
Subunit Kv7.4 of the voltage-gated potassium channel | ||
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other names |
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Properties of human protein | ||
Mass / length primary structure | 77 kilodaltons / 695 amino acids (isoform 1)
71 kilodaton / 641 amino acids (isoform 2) |
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Isoforms | 2 | |
Identifier | ||
Gene names | KCNQ4 DFNA2; DFNA2A; KV7.4 | |
External IDs | ||
Orthologue | ||
human | House mouse | |
Entrez | 9132 | 60613 |
Ensemble | ENSG00000117013 | ENSMUSG00000028631 |
UniProt | P56696 | Q9JK97 |
Refseq (mRNA) | NM_004700 | NM_001081142 |
Refseq (protein) | NP_004691 | NP_001074611 |
Gene locus | Chr 1: 40.78 - 40.84 Mb | Chr 4: 120.7 - 120.75 Mb |
PubMed search | 9132 |
60613
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The Kv7.4 subunit of the voltage-gated potassium channel is a protein encoded by the KCNQ4 gene . It forms a potassium channel, which probably plays a crucial role in the excitability of nerve cells, especially the sensory cells in the cochlea . The channel can either only consist of polymers of the KCNQ4 protein or also contain proteins of the KCNQ3 gene.
KCNQ4 is blocked by linopirdine , XE991 and bepridil and activated and opened by ML213. Clofilium , on the other hand, has no effect.
Individual evidence
- ↑ KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 Homo sapiens (human)
- ↑ UniProt P56696
- ↑ H. Yu et al .: Discovery, Synthesis, and Structure-Activity Relationship of a Series of N-Aryl-bicyclo [2.2.1] heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener . In: ACS Chemical Neuroscience . 2, No. 10, October 2011, pp. 572-577. doi : 10.1021 / cn200065b . PMC PMC3223964 (free full text).