KCNQ4

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Subunit Kv7.4 of the voltage-gated potassium channel
Subunit Kv7.4 of the voltage-gated potassium channel
other names
  • Member of 4 of the KQT subfamily of voltage-gated potassium channels
  • KQT-like 4
  • Potassium channel subunit KvLQT4

Available structural data : 2OVC , 4GOW

Properties of human protein
Mass / length primary structure 77 kilodaltons / 695 amino acids (isoform 1)

71 kilodaton / 641 amino acids (isoform 2)

Isoforms 2
Identifier
Gene names KCNQ4 DFNA2; DFNA2A; KV7.4
External IDs
Orthologue
human House mouse
Entrez 9132 60613
Ensemble ENSG00000117013 ENSMUSG00000028631
UniProt P56696 Q9JK97
Refseq (mRNA) NM_004700 NM_001081142
Refseq (protein) NP_004691 NP_001074611
Gene locus Chr 1: 40.78 - 40.84 Mb Chr 4: 120.7 - 120.75 Mb
PubMed search 9132 60613

The Kv7.4 subunit of the voltage-gated potassium channel is a protein encoded by the KCNQ4 gene . It forms a potassium channel, which probably plays a crucial role in the excitability of nerve cells, especially the sensory cells in the cochlea . The channel can either only consist of polymers of the KCNQ4 protein or also contain proteins of the KCNQ3 gene.

KCNQ4 is blocked by linopirdine , XE991 and bepridil and activated and opened by ML213. Clofilium , on the other hand, has no effect.

Individual evidence

  1. ↑ KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 Homo sapiens (human)
  2. ↑ UniProt P56696
  3. ↑ H. Yu et al .: Discovery, Synthesis, and Structure-Activity Relationship of a Series of N-Aryl-bicyclo [2.2.1] heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener . In: ACS Chemical Neuroscience . 2, No. 10, October 2011, pp. 572-577. doi : 10.1021 / cn200065b . PMC PMC3223964 (free full text).